Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study.

Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study.
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DOI:
10.1001/archneurol.2010.129
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发表时间:
2010-07
影响因子:
--
通讯作者:
Bennett, David A.
Bennett, David A.
中科院分区:
其他
文献类型:
--
作者:
Wilson, Robert S.;Leurgans, Sue E.;Foroud, Tatiana M.;Sweet, Robert A.;Graff-Radford, Neill;Mayeux, Richard;Bennett, David A.

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通过电话管理认知测试电池已被证明是评估认知的一种有效且具有成本效益的手段,但在流行病学研究中仍相对少见。开发综合认知测量,并评估他们分数的变异性与考试管理模式(即,亲自或通过电话)有关的程度。横断面队列研究阿尔茨海默病迟发性家族研究在全美18个中心进行。共有1,584人,其中368人患有痴呆症,来自646个家庭。记忆和认知功能的综合测量得分来自7次绩效测试,这些测试由接受了年度重新认证的结构化绩效培训计划的考官亲自(69%)或通过电话(31%)进行。部分基于对7个测验的因素分析的结果,我们制定了工作记忆、陈述性记忆、情节记忆、语义记忆和全局认知的总结性测量。在线性回归分析中,测试管理模式对测量变量的解释不到2%。在混合效应模型中,由中心引起的认知分数的变异性相对于由于个人和家庭之间的差异而引起的变异性较小。在衰老和阿尔茨海默病的流行病学研究中,通过电话评估认知对绩效影响很小,并提供了操作灵活性和减少成本和丢失数据的手段。
Administration of cognitive test batteries by telephone has been shown to be a valid and cost-effective means of assessing cognition, but it remains relatively uncommon in epidemiological research. To develop composite cognitive measures and assess how much of the variability in their scores is associated with mode of test administration (i.e., in person or by telephone). Cross-sectional cohort study Late Onset of Alzheimer’s Disease Family Study conducted at 18 centers across the United States. A total of 1,584 persons, 368 with dementia, from 646 families. Scores on composite measures of memory and cognitive function derived from a battery of 7 performance tests administered in person (69%) or by telephone (31%) by examiners who underwent a structured performance-based training program with annual recertification. Based in part on the results of a factor analysis of the 7 tests, we developed summary measures of working memory, declarative memory, episodic memory, semantic memory, and global cognition. In linear regression analyses, mode of test administration accounted for less than 2% of the variance in the measures. In mixed-effects models, variability in cognitive scores due to center was small relative to variability due to differences between individuals and families. In epidemiologic research on aging and AD, assessment of cognition by telephone has little effect on performance and provides operational flexibility and a means of reducing costs and missing data.
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