Assessing the optimal virulence of malaria-targeting mosquito pathogens: a mathematical study of engineered Metarhizium anisopliae.
Assessing the optimal virulence of malaria-targeting mosquito pathogens: a mathematical study of engineered Metarhizium anisopliae.
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DOI：
10.1186/1475-2875-13-11
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发表时间：
2014-01-08
期刊：
影响因子：
3
通讯作者：
Coombs D
中科院分区：
文献类型：
--
作者：
Konrad BP;Lindstrom M;Gumpinger A;Zhu J;Coombs D
金龟子绿僵菌是一种自然产生的蚊子真菌病原体。最近，绿僵菌已经被改造成通过直接杀死蚊子媒介中的病原体并有效地阻止继续传播来对抗疟疾。有人建议，应努力将真菌病原体的毒力降至最低，以便在实际部署后减缓抗药性蚊子的发展。建立了两个数学模型并进行了分析，以检验该真菌病原体的有效性。研究发现，在许多合理的情况下，即使对真菌产生抗药性的可能性可以忽略不计，但最好的效果是在病原体毒力降低或最低的情况下实现的。这两个模型的结果取决于两个主要效应之间的相互作用：真菌减少蚊子数量的能力，以及感染真菌的蚊子与未感染真菌的蚊子争夺资源的能力。结果表明，对工程绿僵菌或类似病原菌的毒力没有明显的选择，关于蚊子-真菌组合系统的种群生态的所有现有信息都应仔细考虑。这些模型为检查抗疟疾蚊子病原体提供了一个基本框架，随着新的实验室和现场数据的出现，这些框架应该得到推广和改进。
Metarhizium anisopliae is a naturally occurring fungal pathogen of mosquitoes. Recently, Metarhizium has been engineered to act against malaria by directly killing the disease agent within mosquito vectors and also effectively blocking onward transmission. It has been proposed that efforts should be made to minimize the virulence of the fungal pathogen, in order to slow the development of resistant mosquitoes following an actual deployment. Two mathematical models were developed and analysed to examine the efficacy of the fungal pathogen. It was found that, in many plausible scenarios, the best effects are achieved with a reduced or minimal pathogen virulence, even if the likelihood of resistance to the fungus is negligible. The results for both models depend on the interplay between two main effects: the ability of the fungus to reduce the mosquito population, and the ability of fungus‐infected mosquitoes to compete for resources with non‐fungus‐infected mosquitoes. The results indicate that there is no obvious choice of virulence for engineered Metarhizium or similar pathogens, and that all available information regarding the population ecology of the combined mosquito‐fungus system should be carefully considered. The models provide a basic framework for examination of anti‐malarial mosquito pathogens that should be extended and improved as new laboratory and field data become available.
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