Competitive adsorption of thiolated polyethylene glycol and mercaptopropionic acid on gold nanoparticles measured by physical characterization methods.
Competitive adsorption of thiolated polyethylene glycol and mercaptopropionic acid on gold nanoparticles measured by physical characterization methods.
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DOI：
10.1021/la100484a
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
Hackley VA
中科院分区：
文献类型：
--
作者：
Tsai DH;DelRio FW;MacCuspie RI;Cho TJ;Zachariah MR;Hackley VA
使用结合动态光散射 (DLS) 和电喷雾微分迁移率分析 (ES-DMA) 的原型物理表征方法研究了硫醇化聚乙二醇 (SH-PEG) 和巯基丙酸 (MPA) 在金纳米粒子 (Au-NP) 上的竞争吸附动力学。在二组分（Au-NP + MPA 或 Au-NP + SH-PEG）和三组分（Au-NP + MPA + SH-PEG）系统中，通过 DLS 测量了由于 Au-NP 上 SH-PEG 涂层形成而导致的流体动力学粒径（强度平均）的变化。 ES-DMA 用于量化 SH-PEG 的表面覆盖度，并建立表面覆盖度与 DLS 测量的粒径变化之间的相关性。在不同浓度的 SH-PEG 和 MPA 下，Au-NP 上 SH-PEG 平衡结合常数的变化表明 MPA 的存在降低了 SH-PEG 与 Au-NP 表面的结合亲和力。动力学研究表明，在随后引入 MPA 后，SH-PEG 按照二阶解吸模型从 Au-NP 表面解吸。通过 MPA 置换，SH-PEG 从 Au-NP 表面解吸的速率常数受到 MPA 浓度和溶液中过量 SH-PEG 的强烈影响。
Competitive adsorption kinetics between thiolated polyethylene glycol (SH-PEG) and mercaptopropionic acid (MPA) on gold nanoparticles (Au-NPs) were studied using a prototype physical characterization approach that combines dynamic light scattering (DLS) and electrospray differential mobility analysis (ES-DMA). The change in hydrodynamic particle size (intensity-average) due to the formation of SH-PEG coatings on Au-NPs were measured by DLS in both two component (Au-NP + MPA or Au-NP + SH-PEG) and three component (Au-NP +MPA + SH-PEG) systems. ES-DMA was employed to quantify the surface coverage of SH-PEG and establish a correlation between surface coverage and the change in particle size measured by DLS. A change in equilibrium binding constant for SH-PEG on Au-NPs at various concentrations of SH-PEG and MPA showed that the presence of MPA reduced the binding affinity of SH-PEG to the Au-NP surface. Kinetic studies showed SH-PEG was desorbed from the Au-NP surface following a second-order desorption model after subsequently introducing MPA. The desorption rate constant of SH-PEG from the Au-NP surface by MPA displacement was strongly affected by the concentration of MPA and the excess SH-PEG in solution.
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