COMPARISON OF COMORBID CONDITIONS BETWEEN NEOVASCULAR AGE–RELATED MACULAR DEGENERATION PATIENTS AND A CONTROL COHORT IN THE MEDICARE POPULATION
COMPARISON OF COMORBID CONDITIONS BETWEEN NEOVASCULAR AGE–RELATED MACULAR DEGENERATION PATIENTS AND A CONTROL COHORT IN THE MEDICARE POPULATION
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医疗保险人群中新生血管年龄相关性黄斑变性患者与对照组之间共病状况的比较
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
J. Murphy
中科院分区：
文献类型：
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作者：
G. Zlateva;J. Javitt;Sonali N. Shah;Zhiyuang Zhou;J. Murphy
目的：确定新生血管性年龄相关性黄斑变性 (NV-AMD) 患者的合并症是否比未患 AMD 的患者更普遍。方法：这项为期两年的回顾性病例对照研究包括从 2003 年 1 月 1 日到 2004 年 12 月 31 日连续登记的 Medicare 受益人（标准 5% 分析样本），不包括管理式医疗计划中的受益人。 NV-AMD 队列包括 2003 年和 2004 年诊断为 NV-AMD 的基线年龄≥65 岁的个体。年龄、性别和种族匹配的对照是从没有 AMD 的患者中选择的。根据 ICD-9-CM 代码对 13 种一般类别的非眼科疾病和 18 种特定合并症进行了比较。根据病情和队列计算两年患病率；计算比值比和 99% 置信区间（逻辑回归）。结果：分析包括 26,057 名受试者和同等数量的对照组。几乎所有受试者都至少患有一种合并症，并且每个队列中超过 80% 的受试者在一般疾病类别中患有五种或更多合并症。两个队列中 7/13 一般疾病类别的患病率均超过 50%； NV-AMD 患者中 12/13 类别的发生率显着较高 (P < 0.001)。 NV-AMD 受试者中 13/14 非眼睛相关和 4/4 眼睛相关特定合并症的患病率显着较高（P < 0.05）。 NV-AMD 受试者患高血压、高胆固醇血症、肺气肿、慢性阻塞性肺病、动脉粥样硬化、关节炎、冠心病、白内障、青光眼和近视的几率高出 20% 以上。结论：NV-AMD 患者出现合并症的可能性明显更大，其中许多可能危及生命。
Purpose: To determine whether comorbidities are more prevalent among individuals with neovascular age-related macular degeneration (NV-AMD) than individuals without AMD. Methods: This 2-year, retrospective, case-control study included Medicare beneficiaries (standard 5% analytic sample) continuously enrolled from January 1, 2003, to December 31, 2004, excluding those in managed care plans. The NV-AMD cohort included individuals ≥65 at baseline with a diagnosis of NV-AMD in 2003 and 2004. Age-, gender-, and race-matched controls were selected from those with no AMD. Comparisons were made for 13 general categories of non-eye-related diseases and 18 specific comorbidities based on ICD-9-CM codes. Two-year prevalence was calculated by condition and cohort; odds ratios and 99% confidence intervals were calculated (logistic regression). Results: Analyses included 26,057 subjects and an equal number of controls. Nearly all subjects had at least one comorbidity, and >80% in each cohort had five or more comorbidities across general disease categories. Prevalence of 7/13 general disease categories exceeded 50% in both cohorts; rates for 12/13 categories were significantly higher in those with NV-AMD (P < 0.001). Prevalence of 13/14 non-eye-related and 4/4 eye-related specific comorbidities was significantly higher among NV-AMD subjects (P < 0.05). A more than 20% greater odds for NV-AMD subjects was noted for hypertension, hypercholesterolemia, emphysema, chronic obstructive pulmonary disease, atherosclerosis, arthritis, coronary heart disease, cataract, glaucoma, and myopia. Conclusion: Patients with NV-AMD are significantly more likely to have comorbidities, many of which could be life-threatening.
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影响因子：
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作者：
D. Friedman;S. West;B. Munoz;W. Park;James T. Deremeik;R. Massof;K. Frick;A. Broman;W. McGill
通讯作者：
D. Friedman;S. West;B. Munoz;W. Park;James T. Deremeik;R. Massof;K. Frick;A. Broman;W. McGill
影响因子：
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作者：
CRUICKSHANKS, KJ;KLEIN, R;KLEIN, BEK
通讯作者：
KLEIN, BEK
DOI：
10.1001/jama.1996.03540140029022
发表时间：
1996-10
期刊：
JAMA
影响因子：
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作者：
J. Seddon;W. Willett;F. Speizer;S. Hankinson
通讯作者：
J. Seddon;W. Willett;F. Speizer;S. Hankinson
DOI：
10.1056/nejm199906173402418
发表时间：
1999-06
期刊：
The New England journal of medicine
影响因子：
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作者：
Williams Kj;I. Tabas
通讯作者：
Williams Kj;I. Tabas
影响因子：
13.7
作者：
Leske, MC;Wu, SY;Schachat, AP
通讯作者：
Schachat, AP