The nematode story: Hox gene loss and rapid evolution.
The nematode story: Hox gene loss and rapid evolution.
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线虫的故事：Hox 基因丢失和快速进化。
DOI：
10.1007/978-1-4419-6673-5_7
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发表时间：
2010
影响因子：
--
通讯作者：
Aboobaker A
中科院分区：
文献类型：
--
作者：
Aboobaker A
在绝大多数动物谱系中存在的保守发育控制基因的某些类群中的丢失是一个未充分研究的现象。很可能在那些发生了损失的谱系中，它可能是发育进化的模式、克里思和方向的强烈信号，从而确定了产生形态新颖性的方式。直觉上，我们可能会认为这些新奇事物特别是与形态简化有关的。这方面的一个突出例子发生在线虫中。看来，超过一半的祖先两侧Hox集群已经失去了模式生物秀丽隐杆线虫及其最接近的物种。对线虫门中Hox基因互补序列的研究表明，许多（如果不是所有）这些损失都发生在门内。其他线虫分支与C.秀丽线虫具有额外的Hox基因，其与存在于祖先双侧体中但在模式线虫中缺失的那些基因是直向的。在这些情况下，同源结构域本身的快速序列进化模糊了同源性分配，直到与来自多个线虫进化较慢的Hox基因进化分支的序列进行比较。在整个动物门中，Hox基因的同源结构域正在迅速进化。在一个特定的情况下，两个同源结构域的基因组排列表明了基因丢失的机制。研究C. elegansa有待进一步研究和建立新的线虫模型。然而，我们对Hox基因功能的了解表明，Hox基因作用的遗传回路在C中发生了显着变化。介绍：Hox基因丢失，第三条途径
The loss in some taxa of conserved developmental control genes that are present in the vast majority of animal lineages is an understudied phenomenon. It is likely that in those lineages in which loss has occurred it may be a strong signal of the mode, tempo and direction of developmental evolution and thus identify ways of generating morphological novelties. Intuitively we might expect these novelties to be particularly those associated with morphological simplifications. One striking example of this has occurred within the nematodes. It appears that over half the ancestral bilaterian Hox cluster has been lost from the model organism Caenorhabditis elegans and its closest related species. Studying the Hox gene complement of nematodes across the phylum has shown that many, if not all these losses occurred within the phylum. Other nematode clades only distantly related to C. elegans have additional Hox genes orthologous to those present in the ancestral bilaterian but absent from the model nematode. In some of these cases rapid sequence evolution of the homeodomain itself obscures orthology assignment until comparison is made with sequences from multiple nematode clades with slower evolving Hox genes. Across the phylum the homeodomains of the Hox genes that are present are evolving very rapidly. In one particular case the genomic arrangement of two homeodomains suggests a mechanism for gene loss. Studying the function in nematodes of the Hox genes absent from C. elegansawaits further research and the establishment of new nematode models. However, what we do know about Hox gene functions suggests that the genetic circuits within which Hox genes act have changed significantly within C. elegans and its close relatives.Introduction: Hox Gene Loss, the Third Way
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线虫外阴诱导过程中需要 Hox 基因 lin-39 来选择 Ras 信号传导的结果。
DOI：
10.1242/dev.125.2.181
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Maloof,JN;Kenyon,C
通讯作者：
Kenyon,C
线虫 Hox 基因 egl-5 启动子中顺式调控元件的剖析。
DOI：
10.1016/j.ydbio.2004.09.012
发表时间：
2004
期刊：
Developmental biology.
影响因子：
--
作者：
Teng,Yingqi;Girard,Lisa;Ferreira,HenriqueB;Sternberg,PaulW;Emmons,ScottW
通讯作者：
Emmons,ScottW
影响因子：
64.8
作者：
de Rosa, R;Grenier, JK;Balavoine, G
通讯作者：
Balavoine, G
线虫中的神经元细胞迁移：Hox 基因表达和细胞位置的调节。
DOI：
10.1242/dev.122.10.3117
发表时间：
1996
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Harris,J;Honigberg,L;Robinson,N;Kenyon,C
通讯作者：
Kenyon,C
SAM 结构域蛋白对秀丽隐杆线虫中 Hox 基因表达的全局调节。
影响因子：
11.8
作者：
Zhang,Hong;Azevedo,RicardoBR;Lints,Robyn;Doyle,Christina;Teng,Yingqi;Haber,Daniel;Emmons,ScottW
通讯作者：
Emmons,ScottW