Characterization of vascular strain during in-vitro angioplasty with high-resolution ultrasound speckle tracking.

Characterization of vascular strain during in-vitro angioplasty with high-resolution ultrasound speckle tracking.
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DOI:
10.1186/1742-4682-7-36
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发表时间:
2010-08-20
影响因子:
--
通讯作者:
Weitzel WF
Weitzel WF
中科院分区:
生物学4区
文献类型:
--
作者:
Patel P;Biswas R;Park D;Cichonski TJ;Richards MS;Rubin JM;Phan S;Hamilton J;Weitzel WF

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Ultrasound elasticity imaging provides biomechanical and elastic properties of vascular tissue, with the potential to distinguish between tissue motion and tissue strain. To validate the ability of ultrasound elasticity imaging to predict structurally defined physical changes in tissue, strain measurement patterns during angioplasty in four bovine carotid artery pathology samples were compared to the measured physical characteristics of the tissue specimens. Using computational image-processing techniques, the circumferences of each bovine artery specimen were obtained from ultrasound and pathologic data. Ultrasound-strain-based and pathology-based arterial circumference measurements were correlated with an R2 value of 0.94 (p = 0.03). The experimental elasticity imaging results confirmed the onset of deformation of an angioplasty procedure by indicating a consistent inflection point where vessel fibers were fully unfolded and vessel wall strain initiated. These results validate the ability of ultrasound elasticity imaging to measure localized mechanical changes in vascular tissue.
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