Transcranial direct current stimulation to the left angular gyrus improves verbal learning in amnestic mild cognitive impairment: A case report.
Transcranial direct current stimulation to the left angular gyrus improves verbal learning in amnestic mild cognitive impairment: A case report.
复制标题
经颅直流电刺激左侧角回可改善遗忘性轻度认知障碍患者的言语学习：病例报告。
DOI：
10.1016/j.brs.2023.09.017
复制
发表时间：
2023
影响因子：
7.7
通讯作者：
Tsapkini,Kyrana
中科院分区：
文献类型：
--
作者：
Tao,Yuan;Afthinos,Alexandros;Gallegos,Jessica;Herrmann,Olivia;Frangakis,Constantine;Tsapkini,Kyrana
在这里，我们报告了一种新的经颅直流电刺激（tDCS）治疗遗忘型轻度认知障碍（aMCI）的参与者的行为和神经影像学结果。迄今为止，几乎所有关于aMCI或阿尔茨海默病（AD）的非侵入性神经调节研究都针对背外侧前额叶皮层（DLPFC，参见[1，2]的最新综述），这是额顶中央执行网络的一部分。同时，默认模式网络（DMN）的功能障碍，包括代谢和连接性降低，已越来越多地被认为是除海马萎缩之外的AD病理学的另一个标志[3，4]。在这里，我们使用了一种新的蒙太奇，目标是DMN的外侧顶叶成分，左角回（L_AG），结合语言学习治疗。以前，我们发现L_AG的代谢与神经退行性疾病中的语言学习能力相关[5]。有趣的是，已经发现L_AG在语义和情景记忆之间的交叉点发挥作用[6]。
Here we report the behavioral and neuroimaging outcomes of a novel transcranial direct current stimulation (tDCS) treatment of a participant with amnestic mild cognitive impairment (aMCI). Almost all non-invasive neuromodulation studies on aMCI or Alzheimer’s Disease (AD) to date targeted the dorsal lateral prefrontal cortex (DLPFC, see recent reviews of [1, 2]), a region that is part of the Frontoparietal Central Executive Network. Meanwhile, dysfunction of the default-mode network (DMN), including reduced metabolism and connectivity, has been increasingly recognized as another hallmark of AD pathology besides hippocampal atrophy [3, 4]. Here we used a novel montage that targeted the lateral parietal component of the DMN, the left angular gyrus (L_AG), combined with verbal learning treatment. Previously, we found that the metabolism of the L_AG was associated with verbal learning capacity in neurodegeneration [5]. Interestingly, the L_AG has been found to play a role at the intersection between semantic and episodic memory [6].
影响因子：
13.1
作者：
Marco Sandrini;R. Manenti;Hakan Sahin;M. Cotelli
通讯作者：
Marco Sandrini;R. Manenti;Hakan Sahin;M. Cotelli