Cardiac diastolic dysfunction is associated with cerebral white matter lesions in elderly patients with risk factors for atherosclerosis.
Cardiac diastolic dysfunction is associated with cerebral white matter lesions in elderly patients with risk factors for atherosclerosis.
复制标题
心脏舒张功能障碍与具有动脉粥样硬化危险因素的老年患者的脑白质病变相关。
DOI：
10.1620/tjem.216.99
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Kohno
中科院分区：
文献类型：
--
作者：
H. Masugata;S. Senda;F. Goda;Ayumu Yamagami;Hiroyuki Okuyama;Takeaki Kohno;N. Hosomi;M. Imai;K. Yukiiri;T. Noma;M. Kohno
磁共振成像（MRI）上的脑白色病变被认为是脑缺血性损伤的结果，也是临床卒中的危险因素。本研究旨在探讨老年动脉粥样硬化危险因素患者心脏舒张功能与脑白色病变的关系。研究对象为55例（75 ± 7岁）具有动脉粥样硬化危险因素（包括高血压、糖尿病和血脂异常）的患者。有症状性脑血管事件的患者从研究中排除。脑白色病变定义为在脑MRI上显示高信号区域，根据2003年日本Brain Dock指南评价脑室周围高信号（PVH）程度。应用组织多普勒超声心动图测定二尖瓣环舒张早期峰值速度（E' velocity），并以此作为评价心脏舒张功能的指标。由于心脏舒张功能障碍，E'速度平均值降低（5.2 +/- 1.4 cm/s）。此外，E'流速与PVH程度呈负相关（rho =-0.701，p < 0.001）。逐步回归分析显示，E'速度降低（β系数=-0.42，p = 0.001）和高血压（β系数= 0.31，p = 0.001）是PVH程度的独立决定因素。因此，心脏舒张功能障碍与大脑白色病变的严重程度相关，提示老年患者存在动脉粥样硬化危险因素的心脑联系。
Cerebral white matter lesions on magnetic resonance imaging (MRI) are considered to be the result of brain ischemic injury and a risk factor for clinical stroke. The purpose of this study was to elucidate the relationship between the cardiac diastolic function and cerebral white matter lesions in elderly patients with risk factors for atherosclerosis. The study subjects were 55 patients (75 +/- 7 years) with risk factors for atherosclerosis including hypertension, diabetes mellitus, and dyslipidemia. Patients with symptomatic cerebrovascular events were excluded from the study. Cerebral white matter lesions, which were defined as exhibiting high intensity regions on brain MRI, were evaluated with the degrees of periventricular hyperintensity (PVH) according to the Japanese Brain Dock Guidelines of 2003. Peak early diastolic mitral annular velocity (E' velocity) was measured by tissue Doppler echocardiography, and was used as a parameter of cardiac diastolic function. The mean value of E' velocity was decreased due to the cardiac diastolic dysfunction (5.2 +/- 1.4 cm/s). In addition, the E' velocity was inversely correlated with the degree of PVH (rho = -0.701, p < 0.001). Stepwise regression analysis showed that the decrease in the E' velocity (beta coefficient = -0.42, p < 0.001) and the presence of hypertension (beta coefficient = 0.31, p = 0.001) were independent determinants of the degree of PVH. Thus, cardiac diastolic dysfunction is correlated to the severity of cerebral white matter lesions, suggesting the cardio-cerebral connection in elderly patients with risk factors for atherosclerosis.
影响因子：
5
作者：
L. Chambless;A. Folsom;L. Clegg;A. Sharrett;E. Shahar;F. Nieto;W. Rosamond;G. Evans
通讯作者：
L. Chambless;A. Folsom;L. Clegg;A. Sharrett;E. Shahar;F. Nieto;W. Rosamond;G. Evans
影响因子：
5
作者：
FAZEKAS, F;CHAWLUK, JB;ZIMMERMAN, RA
通讯作者：
ZIMMERMAN, RA