In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder.
In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder.
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在Silico探索扑热息痛和杀虫剂在自闭症谱系障碍病因学中的潜在作用。
DOI：
10.3390/toxics9050097
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发表时间：
2021-04-27
期刊：
影响因子：
4.6
通讯作者：
Vasiliou V
中科院分区：
文献类型：
--
作者：
Furnary T;Garcia-Milian R;Liew Z;Whirledge S;Vasiliou V
最近的流行病学研究表明，产前暴露于对乙酰氨基酚（APAP）与自闭症谱系障碍（ASD）的风险增加有关，ASD是一种神经发育障碍，影响美国59名儿童中的1名。母体和产前暴露于食物和环境来源的农药也有牵连，影响胎儿的神经发育。然而，ASD的潜在机制迄今尚不清楚，可能具有复杂和多因素的病因。本研究的目的是通过突出共同的基因和生物学途径，探索APAP和农药暴露对ASD病因学发育的潜在影响。从分子和生物医学文献数据库中检索通过人类研究与APAP、农药和ASD相关的基因。重叠的遗传协会的相互作用网络进行网络拓扑结构分析和功能注释所产生的集群。这些基因在与细胞凋亡、活性氧（ROS）代谢和碳水化合物代谢相关的途径和生物过程（FDR p < 0.05）中过度表达。由于这三种生物过程经常与ASD有关，我们的研究结果支持细胞死亡过程和特定代谢途径的假设，这两者似乎都是APAP和农药暴露的目标，可能参与ASD的病因学。这种新的自闭症基因疾病数据库挖掘可能会激发未来的工作，了解各种ASD风险因素的生物学基础。
Recent epidemiological studies suggest that prenatal exposure to acetaminophen (APAP) is associated with increased risk of Autism Spectrum Disorder (ASD), a neurodevelopmental disorder affecting 1 in 59 children in the US. Maternal and prenatal exposure to pesticides from food and environmental sources have also been implicated to affect fetal neurodevelopment. However, the underlying mechanisms for ASD are so far unknown, likely with complex and multifactorial etiology. The aim of this study was to explore the potential effects of APAP and pesticide exposure on development with regards to the etiology of ASD by highlighting common genes and biological pathways. Genes associated with APAP, pesticides, and ASD through human research were retrieved from molecular and biomedical literature databases. The interaction network of overlapping genetic associations was subjected to network topology analysis and functional annotation of the resulting clusters. These genes were over-represented in pathways and biological processes (FDR p < 0.05) related to apoptosis, metabolism of reactive oxygen species (ROS), and carbohydrate metabolism. Since these three biological processes are frequently implicated in ASD, our findings support the hypothesis that cell death processes and specific metabolic pathways, both of which appear to be targeted by APAP and pesticide exposure, may be involved in the etiology of ASD. This novel exposures-gene-disease database mining might inspire future work on understanding the biological underpinnings of various ASD risk factors.
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产前空气污染物暴露和孕产妇叶酸对自闭症谱系障碍风险的关节作用。
DOI：
10.1002/aur.1885
发表时间：
2018-01
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
--
作者：
Goodrich AJ;Volk HE;Tancredi DJ;McConnell R;Lurmann FW;Hansen RL;Schmidt RJ
通讯作者：
Schmidt RJ
影响因子：
3.4
作者：
Herbert, M. R.;Russo, J. P.;Hatchwell, E.
通讯作者：
Hatchwell, E.
影响因子：
3.1
作者：
Fotio, A. L.;Nguepi, M. S. D.;Nguelefack, T. B.
通讯作者：
Nguelefack, T. B.
DOI：
10.1016/j.pathophys.2006.05.007
发表时间：
2006-08-01
期刊：
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子：
--
作者：
Chauhan, Abha;Chauhan, Ved
通讯作者：
Chauhan, Ved
DOI：
10.1016/j.bbrc.2006.02.143
发表时间：
2006-04-28
影响因子：
3.1
作者：
James, LP;Donahower, B;Hinson, JA
通讯作者：
Hinson, JA