Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain.
Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain.
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DOI：
10.1155/2014/408503
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Furukawa Y
中科院分区：
文献类型：
--
作者：
Okuyama S;Yamamoto K;Mori H;Toyoda N;Yoshimura M;Amakura Y;Yoshida T;Sugawara K;Sudo M;Nakajima M;Furukawa Y
对日本爱媛县柑橘产品之一的川内柑橘（Citrus kawachiensis）的干果皮粉进行检测，结果表明其含有柚皮苷（NGIN; 44.02 ± 0.491 mg/g），纳洛酮（NRTN; 4.46 ± 0.0563 mg/g; AUR; 4.07 ± 0.033 mg/g; HMF; 0.27 ± 0.0039 mg/g）。当将该干燥的果皮粉末以1.2或2.4g/kg/天的剂量经口预施用到脂多糖（LPS）注射小鼠（全身炎症的动物模型）中7天时，它抑制（1）LPS诱导的体重减轻和在旷场中的异常行为，（2）LPS诱导的海马中小胶质细胞和星形胶质细胞的活化，（3）LPS诱导小鼠星形胶质细胞表达环氧化酶（考克斯）-2。当NGIN或AUR以类似于果皮粉末中的量预先给药于注射LPS的小鼠时，AUR而不是NGIN具有抑制这些模型小鼠脑中LPS诱导的炎症的能力。含有足够量AUR的柑桔外果皮组织（柑桔果实中果皮的外层）和果汁的干燥粉末也具有抗炎作用。这些结果表明，AUR是负责的C干果皮抗炎性的主要成分。川内种
Examination of the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, showed that it contained naringin (NGIN; 44.02 ± 0.491 mg/g), narirutin (NRTN; 4.46 ± 0.0563 mg/g), auraptene (AUR; 4.07 ± 0.033 mg/g), and 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF; 0.27 ± 0.0039 mg/g). When this dried peel powder was orally preadministered at the dose of 1.2 or 2.4 g/kg/day for 7 days into lipopolysaccharide- (LPS-) injected mice, an animal model of systemic inflammation, it suppressed (1) LPS-induced loss of body weight and abnormal behavior in the open field, (2) LPS-induced activation of microglia and astrocytes in the hippocampus, and (3) LPS-induced expression of cyclooxygenase (COX)-2, which were coexpressed in astrocytes of these mice. When NGIN or AUR was preadministered to LPS-injected mice at an amount similar to that in the peel powder, AUR, but not NGIN, had the ability to suppress the LPS-induced inflammation in the brain of these model mice. The dried powder of flavedo tissue (the outer colored layer of the mesocarp of a citrus fruit) and juice, which contained sufficient amounts of AUR, also had anti-inflammatory effect. These results suggest that AUR was the main ingredient responsible for the anti-inflammatory property of the dried peels of C. kawachiensis.
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