Contribution of Dysregulated B-Cells and IgE Antibody Responses to Multiple Sclerosis.
Contribution of Dysregulated B-Cells and IgE Antibody Responses to Multiple Sclerosis.
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DOI：
10.3389/fimmu.2022.900117
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
多发性硬化症 (MS) 是一种影响大脑和脊髓的使人衰弱的自身免疫性炎症性疾病，会导致神经元脱髓鞘、轴突损伤和神经变性。 MS 和小鼠实验性自身免疫性脑脊髓炎 (EAE) 模型主要被视为 T 细胞介导的疾病。新出现的数据表明 B 细胞和自身抗体对疾病进展的贡献。然而，失调的 B 细胞和抗体反应促进 MS 和 EAE 的潜在机制仍不清楚。在此，我们对这一特定主题进行了最新综述，包括 B 细胞生物学和 B 细胞在触发自身免疫性神经炎症中的作用，重点关注产生抗体的 B 细胞的调节。然后我们将讨论特定类型抗体 IgE 的作用，因为它与小胶质细胞和巨噬细胞激活、自身免疫和 MS/EAE 发展的潜在调节有关。这些知识可用于开发新的有效治疗多发性硬化症的方法，这符合研究主题“白质病变的免疫机制：临床和病理生理学影响”的范围。
Multiple sclerosis (MS), a debilitating autoimmune inflammatory disease that affects the brain and spinal cord, causes demyelination of neurons, axonal damage, and neurodegeneration. MS and the murine experimental autoimmune encephalomyelitis (EAE) model have been viewed mainly as T-cell-mediated diseases. Emerging data have suggested the contribution of B-cells and autoantibodies to the disease progression. However, the underlying mechanisms by which dysregulated B-cells and antibody response promote MS and EAE remain largely unclear. Here, we provide an updated review of this specific subject by including B-cell biology and the role of B-cells in triggering autoimmune neuroinflammation with a focus on the regulation of antibody-producing B-cells. We will then discuss the role of a specific type of antibody, IgE, as it relates to the potential regulation of microglia and macrophage activation, autoimmunity and MS/EAE development. This knowledge can be utilized to develop new and effective therapeutic approaches to MS, which fits the scope of the Research Topic “Immune Mechanism in White Matter Lesions: Clinical and Pathophysiological Implications”.
影响因子：
15.3
作者：
Jung, S;Siebenkotten, G;Radbruch, A
通讯作者：
Radbruch, A
影响因子：
15.3
作者：
Lafaille, J J;Keere, F V;Hsu, A L;Baron, J L;Haas, W;Raine, C S;Tonegawa, S
通讯作者：
Tonegawa, S
影响因子：
4.4
作者：
Wang Z;Zhang H;Shen XH;Jin KL;Ye GF;Qiu W;Qian L;Li B;Zhang YH;Shi GP
通讯作者：
Shi GP