Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression
Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression
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人类分化型胃癌在疾病进展过程中从胃上皮细胞类型到肠上皮细胞类型的表型转变
DOI：
10.1007/s101200050007
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发表时间：
1998
期刊：
影响因子：
7.4
通讯作者：
M. Tatematsu
中科院分区：
文献类型：
--
作者：
A. Yoshikawa;K. Inada;T. Yamachika;N. Shimizu;M. Kaminishi;M. Tatematsu
背景肿瘤细胞的表型表达被广泛认为类似于起源组织的表型表达。在本研究中，为了评估随着疾病进展而发生的表型变化，我们研究了不同浸润深度的人分化型胃癌的癌细胞类型。
方法.应用粘蛋白组化和免疫组化相结合的方法，对301例分化型胃癌手术标本进行了分类，根据癌细胞的表型分化，将其分为胃上皮细胞型（G）、肠上皮细胞型（I）和胃肠混合型（GI）。评估了癌的表型类型与其浸润深度之间的关系。
结果早期（肿瘤侵犯粘膜或粘膜下层）G型癌占41.4%，晚期（肿瘤侵犯固有肌层或更深）G型癌占22.2%，而I型癌占23.5%，随病情进展而增加至31.1%（P < 0.01）。浸润浆膜下或更深的癌中I型多于G型，而浸润粘膜的癌中G型少于I型（P < 0.01）。在每种表型的大多数情况下，在周围的背景粘膜中识别出肠上皮化生，但在癌症的表型和背景粘膜中肠上皮化生的程度之间没有明确的关系，这表明肠上皮化生并不总是癌前病变。
结论.随着人分化型胃癌的进展，观察到从G型到I型表达的表型转变。肠化可以独立地发生在癌性和非癌性胃粘膜中。
Background. The phenotypic expression of tumor cells is widely thought to resemble that of the tissue of origin. In the present study, to assess phenotypic changes that occur with disease progression, we investigated human differentiated gastric cancers at different depths of invasion for component cancer cell types.
Methods. Using a combined mucin histochemical and immunohistochemical approach, we classified surgical specimens of 301 differentiated gastric cancers into three types: gastric epithelial cell (G) type, intestinal epithelial cell (I) type and mixed gastric and intestinal (GI) type, according to the phenotypic differentiation of the component cancer cells. The relation between the phenotypic type of cancer and their depth of invasion was evaluated.
Results. The proportion of G type cancers was 41.4% in early (tumor invasion of mucosa or submucosa) cases, decreasing to 22.2% in advanced (tumor invasion of muscularis propia or deeper) cases, whereas the proportion of I type cancers increased with progressive disease from 23.5% to 31.1% (P < 0.01). Cancers invading the subserosa or deeper included more I type cases and fewer G type than cancers limited to the mucosa (P < 0.01). In most cases of each phenotypic type, intestinal metaplasia was recognized in the surrounding background mucosa, but no clear relation was shown between the phenotype of cancers and the degree of intestinal metaplasia in the background mucosa, suggesting that intestinal metaplasia is not always a preneoplastic lesion.
Conclusions. A phenotypic shift from G to I type expression was observed with the progression of human differentiated gastric cancers. Intestinalization may occur independently in cancerous and noncancerous gastric mucosa.
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由特定单克隆抗体鉴定的人结肠磺粘蛋白。
影响因子：
11.2
作者：
Irimura,T;Wynn,DM;Hager,LG;Cleary,KR;Ota,DM
通讯作者：
Ota,DM
影响因子：
11.2
作者：
S. Itzkowitz;M. Yuan;C. Montgomery;T. Kjeldsen;H. Takahashi;W. Bigbee;Y. Kim
通讯作者：
S. Itzkowitz;M. Yuan;C. Montgomery;T. Kjeldsen;H. Takahashi;W. Bigbee;Y. Kim
影响因子：
29.4
作者：
Silberg, DG;Furth, EE;Traber, PG
通讯作者：
Traber, PG
抗人结肠磺粘蛋白的单克隆抗体：其在结肠粘膜、结直肠原发癌和转移瘤中的结合位点的免疫化学检测。
影响因子：
11.2
作者：
Yamori,T;Ota,DM;Cleary,KR;Hoff,S;Hager,LG;Irimura,T
通讯作者：
Irimura,T