Bioinformatics analysis of SRSF1-controlled gene networks in colorectal cancer.
Bioinformatics analysis of SRSF1-controlled gene networks in colorectal cancer.
复制标题
结直肠癌中SRSF1控制基因网络的生物信息学分析
DOI：
10.3892/ol.2017.6900
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发表时间：
2017-11
期刊：
影响因子：
2.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Sheng J;Zhao J;Xu Q;Wang L;Zhang W;Zhang Y
结直肠癌是世界范围内第三大最常见的癌症类型和第四大癌症相关死亡原因。富含丝氨酸/丝氨酸的剪接因子1（SRSF 1）是一种特征明确的致癌因子，通过控制许多选择性剪接事件促进肿瘤发生。然而，有有限的网络分析，从全球的角度来看，研究SRSF 1对结直肠癌的影响。在本研究中，基因本体论（GO）和京都基因和基因组百科全书（KEGG）分析的可用基因调控数据从癌症基因组图谱数据库揭示了丰富的功能和信号通路的SRSF 1。随后，进行Oncomine分析，其证明SRSF 1在许多类型的结肠癌中上调。通过对GeneCards中2,678个SRSF 1相关基因和3,625个结直肠癌基因的重叠分析，确定468个基因为SRSF 1相关结直肠癌基因。GO结果显示，这些重叠的基因主要富集在代谢过程中，对DNA损伤的反应，细胞周期的调节和一些额外的生物学过程。KEGG通路分析显示SRSF 1相关的结直肠癌基因与细胞周期、与癌症进展相关的失调信号通路和结直肠癌信号通路相关。此外，检索相互作用基因/蛋白质数据库的搜索工具和Cytoscape分析表明，468个SRSF 1相关的结直肠癌基因表现出潜在的相互作用网络，其中这些基因在DNA代谢过程，细胞周期调控和细胞凋亡调控中富集。本研究的结果表明，SRSF 1表现出与关键分子的相互作用程度增加，这些关键分子包括NUF 2 NDC 80动粒复合物组分、驱动蛋白家族成员2C、3号染色体的结构维持、ATM丝氨酸/苏氨酸激酶、BRCA 1 DNA修复相关、蛋白激酶DNA活化催化多肽、热休克蛋白90 α家族A类成员1、ras同源家族成员A、以及磷酸酶和张力蛋白同源物。总之，本研究的生物信息学分析表明，SRSF 1可能在结直肠癌的进展和发展中具有关键作用。
Colorectal cancer is the third most common type of cancer and the fourth leading cause of cancer-associated mortality worldwide. Serine/arginine-rich splicing factor 1 (SRSF1) is a well-characterized oncogenic factor that promotes tumorigenesis by controlling a number of alternative splicing events. However, there is limited network analysis, from a global aspect, to study the effect of SRSF1 on colorectal cancer. In the present study, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of available gene regulation data from The Cancer Genome Atlas database revealed the enriched functions and signaling pathways of SRSF1. Subsequently, Oncomine analysis was performed, which demonstrated that SRSF1 was upregulated in a number of types of colon cancer. From overlapping the analysis of 2,678 SRSF1-related genes and 3,625 colorectal cancer genes in GeneCards, 468 genes were identified as SRSF1-related colorectal cancer genes. The GO results revealed that these overlapped genes were primarily enriched in metabolic processes, response to DNA damage, regulation of the cell cycle and a number of additional biological processes. KEGG pathway analysis revealed that SRSF1-related colorectal cancer genes were associated with the cell cycle, deregulated signaling pathways associated with cancer progression and colorectal cancer signaling pathways. In addition, the Search Tool for the Retrieval of Interacting Genes/Proteins database and Cytoscape analysis demonstrated that 468 SRSF1-related colorectal cancer genes exhibit potential interaction networks in which these genes were enriched in DNA metabolic processes, cell cycle regulation and regulation of apoptosis. The results of the present study suggested that SRSF1 exhibited an increased degree of interaction with key molecules, including NUF2 NDC80 kinetochore complex component, kinesin family member 2C, structural maintenance of chromosomes 3, ATM serine/threonine kinase, BRCA1 DNA repair associated, protein kinase DNA-activated catalytic polypeptide, heat shock protein 90 alpha family class A member 1, ras homolog family member A, and phosphatase and tensin homolog. Collectively, the bioinformatics analysis of the present study indicated that SRSF1 may have key functions in the progression and development of colorectal cancer.
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影响因子：
16
作者：
Anczuków O;Akerman M;Cléry A;Wu J;Shen C;Shirole NH;Raimer A;Sun S;Jensen MA;Hua Y;Allain FH;Krainer AR
通讯作者：
Krainer AR
影响因子：
10.5
作者：
McCleland, ML;Gardner, RD;Stukenberg, PT
通讯作者：
Stukenberg, PT
影响因子：
7.4
作者：
Shiraishi T;Terada N;Zeng Y;Suyama T;Luo J;Trock B;Kulkarni P;Getzenberg RH
通讯作者：
Getzenberg RH
影响因子：
11.2
作者：
de Miguel, Fernando J.;Sharma, Ravi D.;Pio, Ruben
通讯作者：
Pio, Ruben
DOI：
10.1016/j.bbrc.2009.10.127
发表时间：
2009-12-25
影响因子：
3.1
作者：
Kaneko, Naoyuki;Miura, Koh;Horii, Akira
通讯作者：
Horii, Akira