Cancer/Testis Antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy.
Cancer/Testis Antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy.
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DOI：
10.1186/1479-5876-9-153
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发表时间：
2011-09-14
影响因子：
7.4
通讯作者：
Getzenberg RH
中科院分区：
文献类型：
--
作者：
Shiraishi T;Terada N;Zeng Y;Suyama T;Luo J;Trock B;Kulkarni P;Getzenberg RH
癌症/睾丸抗原（CTA）是一组重要的蛋白质，通常仅限于正常成人的睾丸，但在几种类型的癌症中异常表达。由于其有限的表达模式，CTA可以作为癌症诊断/预后的独特生物标志物。本研究的目的是确定与根治性前列腺切除术（RP）后前列腺癌（PCa）复发相关的有希望的CTA。使用从72例明显临床定位PCa患者中获得的前列腺组织样本，通过定量多重实时PCR测量5种CTA的表达，中位随访时间为2年（范围，1至14年）。复发组中CEP 55、NUF 2、PBK、TTK等CTA表达明显增高，而PAGE 4表达明显降低。除TTK外，所有CTA均与前列腺切除术Gleason评分显著相关，但均与年龄、分期或术前PSA水平无关。在单变量比例风险模型中，CEP 55（HR = 3.59，95%CI：1.50-8.60），p = 0.004; NUF 2（HR = 2.28，95% CI：1.11-4.67），p = 0.024;和PAGE 4（HR = 0.44，95% CI：0.21-0.93），p = 0.031与PCa复发风险显著相关。然而，结果不再显着调整后，切除术的Gleason评分。据我们所知，这是第一项将CTA确定为生物标志物的研究，可以区分RP后复发和非复发疾病的患者，并强调其对PCa预后和治疗的潜在影响。
The Cancer/Testis Antigens (CTAs) are an important group of proteins that are typically restricted to the testis in the normal adult but are aberrantly expressed in several types of cancers. As a result of their restricted expression patterns, the CTAs could serve as unique biomarkers for cancer diagnosis/prognosis. The aim of this study was to identify promising CTAs that are associated with prostate cancer (PCa) recurrence following radical prostatectomy (RP). The expression of 5 CTAs was measured by quantitative multiplex real-time PCR using prostate tissue samples obtained from 72 patients with apparently clinically localized PCa with a median of two years follow-up (range, 1 to 14 years). The expression of CTAs namely, CEP55, NUF2, PBK and TTK were significantly higher while PAGE4 was significantly lower in patients with recurrent disease. All CTAs with the exception of TTK were significantly correlated with the prostatectomy Gleason score, but none were correlated with age, stage, or preoperative PSA levels. In univariate proportional hazards models, CEP55 (HR = 3.59, 95% CI: 1.50-8.60), p = 0.004; NUF2 (HR = 2.28, 95% CI: 1.11-4.67), p = 0.024; and PAGE4 (HR = 0.44, 95% CI: 0.21-0.93), p = 0.031 were significantly associated with the risk of PCa recurrence. However, the results were no longer significant after adjustment for prostatectomy Gleason score. To our knowledge, this is the first study to identify CTAs as biomarkers that can differentiate patients with recurrent and non-recurrent disease following RP and underscores its potential impact on PCa prognosis and treatment.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
2.8
作者：
Suyama, Takahito;Shiraishi, Takumi;Zeng, Yu;Yu, Wayne;Parekh, Nehal;Vessella, Robert L.;Luo, Jun;Getzenberg, Robert H.;Kulkarni, Prakash
通讯作者：
Kulkarni, Prakash
影响因子：
1.6
作者：
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通讯作者：
Hiraoka, Y
影响因子：
6.4
作者：
Harao, Michiko;Hirata, Shinya;Nishimura, Yasuharu
通讯作者：
Nishimura, Yasuharu
影响因子：
11.5
作者：
Gure, AO;Chua, R;Altorki, NK
通讯作者：
Altorki, NK