Polyphenols by Generating H(2)O(2), Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health.
Polyphenols by Generating H(2)O(2), Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health.
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DOI：
10.3390/antiox9090797
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发表时间：
2020-08-27
期刊：
影响因子：
--
通讯作者：
Kanner J
中科院分区：
文献类型：
--
作者：
Kanner J
人体健康受益于不同多酚分子在饮食中的消耗，主要来源于它们在胃肠道和血液微毛细血管水平的共同活性。在胃、肠和结肠中，多酚作为还原剂，防止脂质过氧化、AGEs/ALE（晚期糖基化终产物/晚期脂质氧化终产物）的产生和吸收以及餐后氧化应激。多酚在血液中的低吸收不支持其作为抗氧化剂的活性，并且其活性机制尚未完全了解。结果来自体外、动物和人体研究，通过相关氧化应激标志物检测。本文综述了多酚类化合物通过产生nM浓度的H2 O2，对细胞和器官是外源性的，它是增加细胞Eustress的信号因子的激活剂。当多酚在血液系统中达到高浓度时，它们产生μM浓度的H2 O2，作为细胞毒性剂和痛苦。用多酚预处理细胞或生物体，通过产生低水平的H2 O2，抑制细胞PTP（蛋白酪氨酸磷酸酶），通过转录Nrf 2（核因子红细胞2相关因子2）轴诱导细胞信号传导，以适应和保护氧化应激。在膳食期间以正确的量和时间摄入多酚在胃肠道（GIT）和血液系统的水平上协同作用，以保持我们生物体中的氧化还原稳态，更好地平衡人体健康。
Human health benefits from different polyphenols molecules consumption in the diet, derived mainly by their common activities in the gastrointestinal tract and at the level of blood micro-capillary. In the stomach, intestine and colon, polyphenols act as reducing agents preventing lipid peroxidation, generation and absorption of AGEs/ALEs (advanced glycation end products/advanced lipid oxidation end products) and postprandial oxidative stress. The low absorption of polyphenols in blood does not support their activity as antioxidants and their mechanism of activity is not fully understood. The results are from in vitro, animal and human studies, detected by relevant oxidative stress markers. The review carries evidences that polyphenols, by generating H2O2 at nM concentration, exogenous to cells and organs, act as activators of signaling factors increasing cell Eustress. When polyphenols attain high concentration in the blood system, they generate H2O2 at µM concentration, acting as cytotoxic agents and Distress. Pre-treatment of cells or organisms with polyphenols, by generating H2O2 at low levels, inhibits cellular PTPs (protein tyrosine phosphatases), inducing cell signaling through transcription of the Nrf2 (nuclear factor erythroid 2-related factor 2) axis of adaptation and protection to oxidation stress. Polyphenols ingestion at the right amount and time during the meal acts synergistically at the level of the gastrointestinal tract (GIT) and blood system, for keeping the redox homeostasis in our organism and better balancing human health.
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影响因子：
4.8
作者：
Bienert, Gerd P.;Moller, Anders L. B.;Jahn, Thomas P.
通讯作者：
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DOI：
10.1016/j.bbrc.2008.11.110
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作者：
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