Medical Applications of Infrared Spectroscopy
Medical Applications of Infrared Spectroscopy
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红外光谱的医学应用
DOI：
--
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
H. Heise
中科院分区：
文献类型：
--
作者：
H. Heise
由于仪器和数据处理的改进，人们对医疗应用的红外光谱范围的兴趣迅速增加。激光的使用对于不同的组织治疗是相当常见的，例如外科手术。基于生物组织对短波近红外辐射的相对透明性的更远距离组织的光学成像仍处于起步阶段。近红外光谱法正在研究作为一种非侵入性的临床工具，以提高对体内过程的理解。一些最热门的研究是为了获得人类肿瘤中与治疗相关的生物学参数。脑血流动力学以及细胞色素aa 3的细胞内还原-氧化（氧化还原）水平（例如在人类新生儿的脑中）是非常令人感兴趣的。进一步的研究涵盖了重要代谢物如血糖的经皮测定。中红外和近红外光谱也可以与离散采样结合使用。样品可以来自各种各样的生物流体，例如全血或衍生流体，或者例如尿结石或甚至在细胞水平的组织样品。红外光谱法可以提供无试剂的多组分分析。特别是，血液基质的定量分析及其在临床实验室中的应用评价已经由我们承担。体外传感器可以基于这种技术。对未来发展的预测是，红外光谱将在接近患者的医疗诊断仪器中发挥重要作用。
Interest in the infrared spectral range for medical applications increases rapidly due to improvements in instrumentation and data processing. The use of lasers is fairly common for different tissue treatments, e.g. surgery. Optical imaging of tissue over greater distances, based on the relative transparency of biological tissue to short-wave near infrared radiation, is still in its infancy. Near infrared spectrometry is being investigated as a non-invasive clinical tool for improved understanding of in vivo processes. Some of the hottest research is carried out to obtain therapy-relevant biological parameters in human tumours. Of great interest is cerebral haemodynamics, as well as the intracellular reduction-oxidation (redox) level of cytochrome aa3, e.g in the brain of human neonates. Further studies cover the transcutaneous determination of important metabolites such as blood glucose. Mid and near infrared spectroscopy can also be exploited in combination with discrete sampling. Samples can be from the great variety of biofluids, such as whole blood or derived fluids, or for example, urinary calculi or tissue samples even at cellular level. IR spectroscopy can deliver reagent-free multicomponent assays. In particular, the quantitative analysis of blood substrates and its evaluation for application in the clinical laboratory have been undertaken by us. Extra-corporal sensors can be based on such technology. The prognosis for future development is that IR spectroscopy will play an important role in medical diagnostic instrumentation close to the patient.
近红外分光光度法监测整个沙鼠大脑中与中风相关的蛋白质和脂质组成的变化。
影响因子：
7.4
作者：
Carney,JM;Landrum,W;Mayes,L;Zou,Y;Lodder,RA
通讯作者：
Lodder,RA