Anticholinergic medication and dental caries status in middle-aged xerostomia patients-a retrospective study.
Anticholinergic medication and dental caries status in middle-aged xerostomia patients-a retrospective study.
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DOI：
10.1016/j.jds.2021.12.014
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发表时间：
2022-07
影响因子：
3.5
通讯作者：
Arany, Szilvia
中科院分区：
文献类型：
--
作者：
Kakkar, Mayank;Barmak, Abdul Basir;Arany, Szilvia
口干症是抗胆碱能(AC)药物最常见的副作用，它阻断唾液分泌的胆碱能神经传递。据报道，AC药物在中年人中的使用增加最显著，我们的目的是探索AC药物的暴露水平是否与抱怨药物导致口干症的中年人的龋病严重程度有关。我们的回顾性研究包括414名自述口干症患者(年龄在45岁到之间)。我们通过龋齿、缺牙或充填牙(DMFT)指数确定龋病状况，并通过AC药物量表(ADS)量化AC药物暴露水平，并通过电子用药记录进行验证。统计分析采用卡方检验和方差分析。协变量包括年龄、性别、吸烟、无牙、合并症、多药、数量和AC药物的类型。总体而言，54%的患者正在服用五种或五种以上的AC药物。抗胆碱类药物的平均用药次数为5.41(±3.44)次，其中抗抑郁药和抗精神病药物最多，为10.63次(±5.79次)。ADS分数越高，缺牙数量越多(p=0.006)。多元线性回归模型显示，服用AC药物的次数、年龄和吸烟状况与DMFT(平均18.7±88.96)分相关。中年口干症患者的龋齿状况被发现反映了药物暴露于AC的水平。我们的发现强调了评估受影响的牙科患者AC药物负担的重要性，以改进临床预防策略和指导跨学科治疗计划。
Xerostomia is the most frequent side effect of anticholinergic (AC) medications, which block the cholinergic neurotransmission of saliva secretion. As the most significant increase in AC medications’ usage reported in middle-aged adults, we aimed to explore whether the level of exposure to AC medication show association with the severity of caries status of middle-aged individuals who complained about medication-induced xerostomia. Our retrospective study included 414 individuals (between 45 and 64 years) with self-reported xerostomia. We determined caries status by the Decayed, Missing, or Filled Teeth (DMFT) index and quantified the level of AC drug exposure by the AC Drug Scale (ADS), verified through electronic medication records. Statistical analyses were performed using chi-square and ANOVA tests. Covariates were age, gender, smoking, edentulism, comorbidities, polypharmacy, number, and the type of AC medications. In total, 54% of patients were taking five or more AC drugs. The mean number of anticholinergics was 5.41 (±3.44), most frequently antidepressants and antipsychotics, among all medications 10.63 (±5.79). Higher ADS scores were associated (p = 0.006) with a higher number of missing teeth. Multiple linear regression model showed that the number of AC medications, age, and smoking status are associated with DMFT (mean of 18.7 ± 8.96) scores. Caries status of middle-aged xerostomia patients was found to be reflective of the level of AC exposure from medications. Our finding emphasizes the importance of assessing AC medication burden in affected dental patients to improve clinical prevention strategies and guide interdisciplinary treatment plans.
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DOI：
10.1016/j.oooo.2021.08.015
发表时间：
2021-12
影响因子：
2.9
作者：
Arany, Szilvia;Kopycka-Kedzierawski, Dorota T.;Caprio, Thomas, V;Watson, Gene E.
通讯作者：
Watson, Gene E.
DOI：
10.1177/10454411930040031301
发表时间：
1993-01-01
期刊：
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
影响因子：
--
作者：
BILLINGS, RJ
通讯作者：
BILLINGS, RJ
DOI：
10.1034/j.1600-0528.2002.300309.x
发表时间：
2002-06-01
影响因子：
2.3
作者：
Thomson, WM;Spencer, AJ;Chalmers, JM
通讯作者：
Chalmers, JM
影响因子：
6.3
作者：
Radcliff, Sue;Yue, Jirong;Beers, Mark H.
通讯作者：
Beers, Mark H.
DOI：
10.1001/jama.2016.14403
发表时间：
2016-10-11
期刊：
JAMA
影响因子：
--
作者：
Kantor ED;Rehm CD;Du M;White E;Giovannucci EL
通讯作者：
Giovannucci EL