Signal Transduction Pathways in Ageing.

Signal Transduction Pathways in Ageing.
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衰老中的信号转导途径。

DOI:
10.1007/978-981-13-2835-0_11
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发表时间:
2018
影响因子:
--
通讯作者:
Slack C
Slack C
中科院分区:
--
文献类型:
--
作者:
Slack C

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现在人们普遍认识到,衰老及其相关的功能衰退受到一系列分子的调控,这些分子适合于特定的细胞途径。在这里,我们描述了几种控制生物衰老的进化保守的细胞信号通路,并讨论了它们的识别和对促成它们的单个分子的作用如何有助于设计治疗策略,以减轻衰老和与年龄相关的疾病的不利影响。
It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.
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