Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction--a novel mechanism for maintaining vascular function.
Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction--a novel mechanism for maintaining vascular function.
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DOI：
10.1186/s13045-014-0080-6
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发表时间：
2014-10-31
影响因子：
28.5
通讯作者：
Yang XF
中科院分区：
文献类型：
--
作者：
Shao Y;Cheng Z;Li X;Chernaya V;Wang H;Yang XF
内皮功能障碍是血管系统的一种病理状态，其可以广义地定义为内皮依赖性血管收缩和血管舒张之间的失衡。内皮功能障碍是许多病理过程包括动脉粥样硬化、II型糖尿病和高血压进展中的关键事件。先前的报道已经证明，促炎/免疫效应细胞因子显著促进内皮功能障碍，而许多新的抗炎/免疫抑制细胞因子最近已被鉴定，如白细胞介素（IL）-35。然而，抗炎细胞因子对内皮功能障碍的影响却很少受到关注。在这篇分析性综述中，我们重点介绍了抗炎/免疫抑制细胞因子在抑制内皮功能障碍中的直接和间接作用的最新进展。我们的分析不仅限于内皮功能障碍在心血管疾病进展中的重要性，而且还扩展到抗炎/免疫抑制细胞因子抑制内皮功能障碍的分子机制和途径。我们的综述表明，抗炎/免疫抑制细胞因子作为抑制内皮功能障碍，血管炎症和心血管疾病的新的治疗目标。本文的在线版本（doi：10.1186/s13045-014-0080-6）包含补充材料，可供授权用户使用。
Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro-inflammatory/immunoeffector cytokines significantly promote endothelial dysfunction while numerous novel anti-inflammatory/immunosuppressive cytokines have recently been identified such as interleukin (IL)-35. However, the effects of anti-inflammatory cytokines on endothelial dysfunction have received much less attention. In this analytical review, we focus on the recent progress attained in characterizing the direct and indirect effects of anti-inflammatory/immunosuppressive cytokines in the inhibition of endothelial dysfunction. Our analyses are not only limited to the importance of endothelial dysfunction in cardiovascular disease progression, but also expand into the molecular mechanisms and pathways underlying the inhibition of endothelial dysfunction by anti-inflammatory/immunosuppressive cytokines. Our review suggests that anti-inflammatory/immunosuppressive cytokines serve as novel therapeutic targets for inhibiting endothelial dysfunction, vascular inflammation and cardio- and cerebro-vascular diseases. The online version of this article (doi:10.1186/s13045-014-0080-6) contains supplementary material, which is available to authorized users.
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影响因子：
10.8
作者：
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通讯作者：
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