Current status and future directions of gene expression profiling in Parkinson's disease.
Current status and future directions of gene expression profiling in Parkinson's disease.
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DOI：
10.1016/j.nbd.2010.10.022
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发表时间：
2012-01
影响因子：
6.1
通讯作者：
Greene, James G.
中科院分区：
文献类型：
--
作者：
Greene, James G.
关键词：
帕金森病（PD）是一种常见的年龄相关性神经退行性疾病。运动症状是PD的主要组成部分，但非运动症状，如痴呆，抑郁症和植物神经功能障碍也越来越受到重视。运动症状主要由中脑中黑质多巴胺（SNDA）神经元的选择性变性引起;非运动症状可能与神经轴多个水平的明确描述的病理学有关。对症治疗和疾病缓解治疗的发展依赖于对PD发病机制和病理生理学的准确和全面的理解。基因表达谱最近已被用来评估功能在一个广泛的水平上，希望获得更多的知识，关于如何个别的疾病机制作为一个整体，并产生新的假说，PD发病机制，诊断和进展。到目前为止，大多数研究都是在帕金森病患者的死后大脑样本上进行的，但最近，研究已经针对多巴胺神经元的富集群体，并开始探索黑质外神经元甚至外周组织。这篇综述将提供一个简短的概要基因表达谱在帕金森氏症和它的陷阱，并提出了几个潜在的未来方向和使用的技术。它将侧重于使用微阵列实验来刺激有关PD神经退行性变机制的假设，因为迄今为止大多数研究都解决了这个复杂的问题。
Parkinson’s disease (PD) is a common age-associated neurodegenerative disorder. Motor symptoms are the cardinal component of PD, but non-motor symptoms, such as dementia, depression, and autonomic dysfunction are being increasingly recognized. Motor symptoms are primarily caused by selective degeneration of substantia nigra dopamine (SNDA) neurons in the midbrain; non-motor symptoms may be referable to well-described pathology at multiple levels of the neuraxis. Development of symptomatic and disease-modifying therapies is dependent on an accurate and comprehensive understanding of the pathogenesis and pathophysiology of PD. Gene expression profiling has been recently employed to assess function on a broad level in the hopes of gaining greater knowledge concerning how individual mechanisms of disease fit together as a whole and to generate novel hypotheses concerning PD pathogenesis, diagnosis, and progression. So far, the majority of studies have been performed on postmortem brain samples from PD patients, but more recently, studies have targeted enriched populations of dopamine neurons and have begun to explore extra-nigral neurons and even peripheral tissues. This review will provide a brief synopsis of gene expression profiling in parkinsonism and its pitfalls to date and propose several potential future directions and uses for the technique. It will focus on the use of microarray experiments to stimulate hypotheses concerning mechanisms of neurodegeneration in PD, since the majority of studies thus far have addressed that complicated issue.
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影响因子：
3.7
作者：
Lebouvier T;Neunlist M;Bruley des Varannes S;Coron E;Drouard A;N'Guyen JM;Chaumette T;Tasselli M;Paillusson S;Flamand M;Galmiche JP;Damier P;Derkinderen P
通讯作者：
Derkinderen P
影响因子：
5.3
作者：
Miller, RM;Callahan, LM;Federoff, HJ
通讯作者：
Federoff, HJ
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
8.6
作者：
Adler, CH
通讯作者：
Adler, CH
影响因子：
4.4
作者：
Mundel, S;Grünblatt, E;Youdim, MBH
通讯作者：
Youdim, MBH