Orchestrating Opiate-Associated Memories in Thalamic Circuits.
Orchestrating Opiate-Associated Memories in Thalamic Circuits.
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DOI：
10.1016/j.neuron.2020.06.028
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发表时间：
2020-09-23
期刊：
影响因子：
16.2
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Keyes PC;Adams EL;Chen Z;Bi L;Nachtrab G;Wang VJ;Tessier-Lavigne M;Zhu Y;Chen X
扰乱将环境线索与毒品经历联系起来的记忆有望治疗成瘾。然而，访问存储这些记忆的分布式神经网络是具有挑战性的。在这里，我们表明，丘脑室旁核（PVT）通过向杏仁核（CeA）和杏仁核（NAc）的投射协调阿片相关记忆的获得和维持。PVT→CeA活性将吗啡奖赏与环境联系起来，而在恢复过程中对PVT→NAc通路的短暂抑制会对阿片类药物引发的复发产生持久的保护作用。使用全脑活动映射，我们揭示了非复发小鼠中改变的分布式网络活动，这使我们能够发现激活下游NAc→外侧下丘脑（LH）通路也可以防止复发。这些发现确立了PVT作为阿片相关记忆网络中的关键节点，并证明了靶向PVT→NAc→LH通路治疗阿片成瘾的潜力。PVT通过不同的下游靶点控制阿片相关记忆的形成和维持，并且PVT→NAc→LH通路的操纵防止阿片类药物使用的复发。
Disrupting memories that associate environmental cues with drug experiences holds promise for treating addiction. Yet accessing the distributed neural network that stores such memories is challenging. Here we show that the paraventricular nucleus of the thalamus (PVT) orchestrates the acquisition and maintenance of opiate-associated memories via projections to the central nucleus of the amygdala (CeA) and nucleus accumbens (NAc). PVT→CeA activity associates morphine reward to the environment, whereas transient inhibition of the PVT→NAc pathway during retrieval causes enduring protection against opiate-primed relapse. Using brain wide activity mapping, we revealed distributed network activities that are altered in non-relapsing mice, which enabled us to find that activating the downstream NAc→lateral hypothalamus (LH) pathway also prevents relapse. These findings establish the PVT as a key node in the opiate-associated memory network and demonstrate the potential of targeting the PVT→NAc→LH pathway for treating opioid addiction. The PVT controls the formation and maintenance of opiate-associated memories through distinct downstream targets, and manipulation of the PVT→NAc→LH pathway prevents relapse to opioid use.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
DOI：
10.1037/0097-7403.32.2.135
发表时间：
2006-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
Rescorla, RA
通讯作者：
Rescorla, RA
影响因子：
64.8
作者：
Nader, K;Schafe, GE;Le Doux, JE
通讯作者：
Le Doux, JE
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K