Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER-based study.
Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER-based study.
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胃癌肝、肺、骨和脑转移的频率和临床病理特征：一项基于 SEER 的研究
DOI：
10.1002/cam4.1661
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发表时间：
2018-08
期刊：
影响因子：
4
通讯作者：
Xu RH
中科院分区：
文献类型：
--
作者：
Qiu MZ;Shi SM;Chen ZH;Yu HE;Sheng H;Jin Y;Wang DS;Wang FH;Li YH;Xie D;Zhou ZW;Yang DJ;Xu RH
胃癌（GC）的血行转移模式尚未得到充分探索。在这里，我们分析了胃癌患者肝、肺、骨和脑转移的频率和临床病理特征。该分析查询的数据包括 2010 年至 2014 年监测、流行病学和最终结果计划数据库中的 GC 患者。所有统计分析均使用 Intercooled Stata 13.0（德克萨斯州大学城的 Stata Corporation）进行。所有统计检验都是双面的。总共有 19 022 名符合分析条件的患者。诊断时，IV期患者7792例，其中肝转移3218例（41.30%），肺转移1126例（14.45%），骨转移966例（12.40%），脑转移151例（1.94%）。有肺或肝转移的胃癌患者比无肺或肝转移的患者发生骨和脑转移的风险更高。肠型亚型肝、肺转移率明显较高，而弥漫型更易发生骨转移。近端胃发生转移的风险明显高于远端胃。非裔美国人发生肝转移的风险最高，白种人发生肺转移和脑转移的风险最高。肝、肺、骨和脑转移患者的中位生存期分别为 4 个月、3 个月、4 个月和 3 个月。评估伴有肺或肝转移的GC患者的骨和脑转移状况很重要。了解转移模式有助于临床医生为GC患者设计个性化的治疗前影像学评估。
The hematogenous metastatic pattern of gastric cancer (GC) was not fully explored. Here we analyzed the frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from GC patients. Data queried for this analysis included GC patients from the Surveillance, Epidemiology, and End Results Program database from 2010 to 2014. All of statistical analyses were performed using the Intercooled Stata 13.0 (Stata Corporation, College Station, TX). All statistical tests were two‐sided. Totally, there were 19 022 eligible patients for analysis. At the time of diagnosis, there were 7792 patients at stage IV, including 3218 (41.30%) patients with liver metastasis, 1126 (14.45%) with lung metastasis, 966 (12.40%) with bone metastasis and 151 (1.94%) with brain metastasis. GC patients with lung or liver metastasis have a higher risk of bone and brain metastasis than those without lung nor liver metastasis. Intestinal subtype had significantly higher rate of liver and lung metastasis, while diffuse type was more likely to have bone metastasis. Proximal stomach had significantly higher risk to develop metastasis than distal stomach. African‐Americans had the highest risk of liver metastasis and Caucasian had the highest prone to develop lung and brain metastasis. The median survival for patients with liver, lung, bone, and brain metastasis was 4 months, 3 months, 4 months and 3 months, respectively. It is important to evaluate the status of bone and brain metastasis in GC patients with lung or liver metastasis. Knowledge of metastatic patterns is helpful for clinicians to design personalized pretreatment imaging evaluation for GC patients.
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影响因子：
2.6
作者：
Guadagni, S;Catarci, M;Carboni, M
通讯作者：
Carboni, M
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Jim MA;Pinheiro PS;Carreira H;Espey DK;Wiggins CL;Weir HK
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Weir HK
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影响因子：
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作者：
RHOMBERG, W;GRUBER, U
通讯作者：
GRUBER, U