Deep Brain Stimulation: In Search of Reliable Instruments for Assessing Complex Personality-Related Changes.
Deep Brain Stimulation: In Search of Reliable Instruments for Assessing Complex Personality-Related Changes.
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DOI：
10.3390/brainsci6030040
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发表时间：
2016-09-07
期刊：
影响因子：
3.3
通讯作者：
Christen M
中科院分区：
文献类型：
--
作者：
Ineichen C;Baumann-Vogel H;Christen M
在过去的25年中，超过100，000名患者接受了脑深部电刺激（DBS）治疗。虽然人类临床和动物临床前研究揭示了复杂的大脑信号干扰，帕金森病（PD），当涉及到DBS干预后复杂的心理社会变化时，可用的信息较少。在这篇文章中，我们建议通过精致可靠的仪器更彻底地调查脑深部电刺激后复杂的性格相关变化，以帮助患者及其亲属在手术后阶段。通过追求这一目标，我们首先概述了DBS的临床重要性，然后讨论了伴随DBS干预的问题和不希望的非运动问题。在提供了一个简单的定义复杂的变化，我们继续通过概述测量问题复杂的变化与非运动症状目前相关。后一种情况证实，需要完善的工具，能够有效地评估与人格有关的变化。在提供了一个简短的段落，关于人格的概念，我们认为，后者是显着影响某些能力，目前只发挥一个切线的作用，在临床DBS话语。提高对后一种情况的认识在DBS的背景下是至关重要的，因为它可以阐明能力和人格相关变化的出现之间的联系，例如与患者及其亲属相关的新发冲动控制障碍。最后，我们阐述了能够测量人格相关变化的工具的应用领域。
During the last 25 years, more than 100,000 patients have been treated with Deep Brain Stimulation (DBS). While human clinical and animal preclinical research has shed light on the complex brain-signaling disturbances that underpin e.g., Parkinson’s disease (PD), less information is available when it comes to complex psychosocial changes following DBS interventions. In this contribution, we propose to more thoroughly investigate complex personality-related changes following deep brain stimulation through refined and reliable instruments in order to help patients and their relatives in the post-surgery phase. By pursuing this goal, we first outline the clinical importance DBS has attained followed by discussing problematic and undesired non-motor problems that accompany some DBS interventions. After providing a brief definition of complex changes, we move on by outlining the measurement problem complex changes relating to non-motor symptoms currently are associated with. The latter circumstance substantiates the need for refined instruments that are able to validly assess personality-related changes. After providing a brief paragraph with regard to conceptions of personality, we argue that the latter is significantly influenced by certain competencies which themselves currently play only a tangential role in the clinical DBS-discourse. Increasing awareness of the latter circumstance is crucial in the context of DBS because it could illuminate a link between competencies and the emergence of personality-related changes, such as new-onset impulse control disorders that have relevance for patients and their relatives. Finally, we elaborate on the field of application of instruments that are able to measure personality-related changes.
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