Corpus Callosum Shape Is Altered in Individuals With Nonsyndromic Cleft Lip and Palate
Corpus Callosum Shape Is Altered in Individuals With Nonsyndromic Cleft Lip and Palate
复制标题
非综合征性唇裂和腭裂患者的胼胝体形状发生改变
DOI：
10.1002/ajmg.a.35835
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发表时间：
2013
影响因子：
2
通讯作者：
P. Nopoulos
中科院分区：
文献类型：
--
作者：
S. Weinberg;T. Parsons;Melissa R. Fogel;Courtney P. Walter;A. Conrad;P. Nopoulos
Individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) have altered brain structure compared with healthy controls. Preliminary evidence suggests that the corpus callosum may be dysmorphic in orofacial clefting; however, this midline brain structure has not been systematically assessed in this population. The goal of the present study was to carry out a morphometric assessment of the corpus callosum and its relationship to cognitive performance in a well‐characterized patient cohort with orofacial cleft. Midline brain images were obtained from previously collected MRI scans of 24 CL/P subjects and 40‐adult‐male controls. Eight landmarks on the corpus callosum were digitized on each image and their x,y coordinate locations saved. A geometric morphometrics analysis was applied to the landmark coordinate data to test for shape differences across groups. The relationship between corpus callosum shape and IQ was explored with nonparametric correlation coefficients. Results revealed significant differences in mean corpus callosum shape between CL/P cases and controls (P = 0.029). The CL/P corpus callosum was characterized by increased overall convexity resulting from a superior and posterior displacement. Within CL/P cases, increased corpus callosum shape dysmorphology was moderately correlated with reduced performance IQ (r = 0.546). These results provide additional evidence that midline brain changes may be an important part of the orofacial cleft phenotype. © 2013 Wiley Periodicals, Inc.
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影响因子：
3.7
作者：
Sowell, Elizabeth R.;Peterson, Bradley S.;Toga, Arthur W.
通讯作者：
Toga, Arthur W.
影响因子：
3.7
作者：
Goldstein, JM;Seidman, LJ;Tsuang, MT
通讯作者：
Tsuang, MT
前脑无裂畸形的胚胎起源：发育中的大脑和面部的相互关系。
DOI：
--
发表时间：
1982
期刊：
Scanning electron microscopy
影响因子：
--
作者：
Sulik,KK;Johnston,MC
通讯作者：
Johnston,MC
用于研究大脑结构和功能的图像处理：问题和程序。
DOI：
10.1176/jnp.4.2.125
发表时间：
1992
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
Andreasen,NC;Cohen,G;Harris,G;Cizadlo,T;Parkkinen,J;Rezai,K;Swayze2nd,VW
通讯作者：
Swayze2nd,VW
影响因子：
11
作者：
CASANOVA, MF;SANDERS, RD;WEINBERGER, DR
通讯作者：
WEINBERGER, DR