Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review.
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review.
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DOI：
10.1007/s10555-013-9441-9
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发表时间：
2013-12
影响因子：
9.2
通讯作者：
Sarkar, Fazlul H.
中科院分区：
文献类型：
--
作者：
Azmi, Asfar S.;Bao, Bin;Sarkar, Fazlul H.
生物物质跨膜运输是进化保守机制，是任何正常细胞稳态的一部分。这种转运包括主动、被动、通过微粒和囊泡转运（外来体）的输出，其共同维持重要的微分子和大分子的适当区室化。在病理状态下，例如癌症，输出机制的异常活性导致许多关键蛋白质和microRNA的排出，导致它们的错误表达。外泌体介导的细胞内药物的排出可能是大多数常用治疗剂、靶向剂及其细胞内代谢物的适当作用的另一个障碍。在过去的十年中，许多研究已经揭示了外来体串扰和/或影响主要的肿瘤相关途径，例如缺氧驱动的EMT、癌症干细胞、血管生成和肿瘤微环境中涉及许多细胞类型的转移。新出现的证据表明，外泌体分泌的蛋白质也可以促进成纤维细胞生长，导致促纤维增生反应（DR）;这是有效癌症药物递送的主要障碍。这篇全面的综述强调了对外泌体分泌生物学的理解以及对癌症耐药性的影响。我们提出，成功结合癌症治疗来解决外泌体介导的耐药性需要对这些细胞排斥机制以及分泌的生物分子如何参与肿瘤微环境中的细胞串扰进行跨学科的理解。
Trafficking of biological material across membranes is an evolutionary conserved mechanism and is part of any normal cell homeostasis. Such transport is comprised of active, passive, export through microparticles and vesicular transport (exosomes) that collectively maintain proper compartmentalization of important micro and macromolecules. In pathological states, such as cancer, aberrant activity of export machinery results in expulsion of a number of key proteins and microRNAs resulting in their misexpression. Exosome mediated expulsion of intracellular drugs could be another barrier in the proper action of most of the commonly used therapeutics, targeted agents and their intracellular metabolites. Over the last decade, a number of studies have revealed that exosomes cross-talk and/or influence major tumor related pathways such as hypoxia driven EMT, cancer stemness, angiogenesis and metastasis involving many cell types within the tumor microenvironment. Emerging evidence suggest that exosome secreted proteins can also propel fibroblast growth, resulting in Desmoplastic reaction (DR); a major barrier in effective cancer drug delivery. This comprehensive review highlights the advancements in the understanding of the biology of exosomes secretions and the consequence on cancer drug resistance. We propose that the successful combination of cancer treatments to tackle exosome mediated drug resistance requires an interdisciplinary understanding of these cellular exclusion mechanisms, and how secreted biomolecules are involved in cellular cross-talk within the tumor microenvironment.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1161/atvbaha.112.300139
发表时间：
2013-02
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Boon RA;Vickers KC
通讯作者：
Vickers KC
影响因子：
11.2
作者：
Bobrie, Angelique;Krumeich, Sophie;Thery, Clotilde
通讯作者：
Thery, Clotilde
影响因子：
7.8
作者：
Albertini, M;Pemberton, LF;Blobel, G
通讯作者：
Blobel, G
影响因子：
13.6
作者：
Borges, Fernanda T.;Melo, Sonia A.;Kalluri, Raghu
通讯作者：
Kalluri, Raghu