Decreased functional connectivity of the salience network during narrative comprehension in children with reading difficulties: An fMRI study.
Decreased functional connectivity of the salience network during narrative comprehension in children with reading difficulties: An fMRI study.
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DOI：
10.1016/j.nicl.2018.10.006
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Horowitz-Kraus T
中科院分区：
文献类型：
--
作者：
Twait E;Farah R;Horowitz-Kraus T
阅读障碍是一种神经生物学上的学习障碍，反映在书面（即阅读）的缺陷上，而不是口头语言的缺陷。由于书面语言和口头语言依赖于认知控制能力，我们的目的是在功能性MRI叙事理解任务中比较阅读障碍儿童与典型读者中与认知控制相关的未被研究的显著性网络的功能连通性。尽管阅读障碍儿童的理解水平与典型读者相似，但神经影像学数据显示，阅读障碍儿童与显著性网络相关的独立成分（IC）的功能连接值显著降低。阅读障碍患者显著性网络IC功能连接值与工作记忆行为数据呈负相关。这些发现进一步表明，阅读障碍是通过与EF相关的神经回路的非典型参与表现出来的，特别是在参与叙述时的突出网络。由于显著性网络与转换能力和错误检测有关，未来的研究应侧重于在生命早期加强这些能力，以获得更好的未来阅读效果。行为数据支持阅读障碍者的执行功能和阅读缺陷。典型阅读者显著性网络IC的功能连通性高于阅读障碍者。显著性网络功能连通性与工作记忆能力和处理速度呈负相关
Dyslexia is a neurobiological learning disability, reflected through deficits in written (i.e. reading) but not in spoken language. Since written and spoken language rely on cognitive control abilities, we aimed to compare functional connectivity of the understudied salience network which is related to cognitive control in children with dyslexia vs. typical readers during a functional MRI narrative comprehension task. Although children with dyslexia showed similar comprehension levels as typical readers, neuroimaging data revealed children with dyslexia showed significantly decreased functional connectivity values of an independent component (IC) related to the salience network. The functional connectivity values in the salience network IC were negatively correlated with behavioral data of working memory in those with dyslexia. These findings further express that dyslexia is manifested through atypical involvement of neural circuits related to EF, specifically the salience network even when attending narratives. Since the salience network is related to switching abilities and error detection, future research should focus on strengthening these abilities early in life for better future reading outcomes. Behavioral data supports executive functioning and reading deficiencies in dyslexia Significant greater functional connectivity in the salience network IC in typical readers vs children with dyslexia Negative correlation between functional connectivity of the salience network, working memory abilities and processing speed
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DOI：
10.1016/j.nicl.2015.06.010
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Horowitz-Kraus T;DiFrancesco M;Kay B;Wang Y;Holland SK
通讯作者：
Holland SK
影响因子：
2.3
作者：
Horowitz-Kraus, Tzipi;Holland, Scott K.
通讯作者：
Holland, Scott K.
影响因子：
2.6
作者：
Horowitz-Kraus, Tzipi;Vannest, Jennifer J.;Holland, Scott K.
通讯作者：
Holland, Scott K.
影响因子：
1.9
作者：
Horowitz-Kraus, Tzipi;Breznitz, Zvia
通讯作者：
Breznitz, Zvia
影响因子：
4.7
作者：
Horowitz-Kraus, Tzipi;Breznitz, Zvia
通讯作者：
Breznitz, Zvia