A Preoperative Nomogram for the Prediction of High-Volume Central Lymph Node Metastasis in Papillary Thyroid Carcinoma.
A Preoperative Nomogram for the Prediction of High-Volume Central Lymph Node Metastasis in Papillary Thyroid Carcinoma.
复制标题
预测甲状腺乳头状癌大量中央淋巴结转移的术前列线图
DOI：
10.3389/fendo.2021.753678
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Lin P;Liang F;Ruan J;Han P;Liao J;Chen R;Luo B;Ouyang N;Huang X
研究背景高淋巴结转移（HVLNM，≥ 5个淋巴结）是甲状腺乳头状癌（PTC）复发风险高的不良特征之一，被推荐为初次行甲状腺叶切除术的患者行甲状腺完全切除术的指征之一。在这项研究中，我们的目的是开发一个术前诺模图预测HVLNM在中央室的PTC（cT 1 - 2N 0 M0），其中术前成像技术表现不佳。方法收集2016年10月至2021年4月在我中心行甲状腺全切除术和预防性中央间室颈淋巴结清扫术的PTC患者423例。记录人口统计学和临床病理学特征，并采用单因素和多因素Logistic回归分析。基于多变量逻辑回归分析建立列线图。结果57例（13.4%）中央室HVLNM。单变量和多变量logistic回归分析显示，年龄（</=35岁vs>35岁）、BRAF伴V600 E突变、结节直径和钙化独立预测中央室HVLNM。列线图显示出良好的区分度，AUC为0.821（95% CI，0.768-0.875）。结论术前诺模图可定量评估中央室HVLNM的发生概率，降低甲状腺叶切除术后再手术率。
Background High-volume lymph node metastasis (HVLNM, equal to or more than 5 lymph nodes) is one of the adverse features indicating high recurrence risk in papillary thyroid carcinoma (PTC) and is recommended as one of the indications of completion thyroidectomy for patients undergoing thyroid lobectomy at first. In this study, we aim to develop a preoperative nomogram for the prediction of HVLNMs in the central compartment in PTC (cT1-2N0M0), where preoperative imaging techniques perform poor. Methods From October 2016 to April 2021, 423 patients were included, who were diagnosed as PTC (cT1-2N0M0) and underwent total thyroidectomy and prophylactic central compartment neck dissection in our center. Demographic and clinicopathological features were recorded and analyzed using univariate and multivariate logistic regression analysis. A nomogram was developed based on multivariate logistic regression analysis. Results Among the included patients, 13.4% (57 cases) were found to have HVLNMs in the central compartment. Univariate and multivariate logistic regression analysis showed that age (</=35 years vs. >35 years), BRAF with V600E mutated, nodule diameter, and calcification independently predicted HVLNMs in the central compartment. The nomogram showed good discrimination with an AUC of 0.821 (95% CI, 0.768–0.875). Conclusion The preoperative nomogram can be used to quantify the probability of HVLNMs in the central compartment and may reduce the reoperation rate after thyroid lobectomy.
登录
查看更多内容
通过 ARMS-PCR 进行 BRAF 突变分析改进甲状腺结节管理
影响因子：
3.2
作者：
Li, Xinyang;Li, Enling;Zheng, Bing
通讯作者：
Zheng, Bing
乳头状甲状腺微核瘤患者的宫颈淋巴转移风险因素的临床分析。
影响因子：
5.4
作者：
Luo Y;Zhao Y;Chen K;Shen J;Shi J;Lu S;Lei J;Li Z;Luo D
通讯作者：
Luo D
影响因子：
6.6
作者：
Jonklaas, Jacqueline;Sarlis, Nicholas J.;Sherman, Steven I.
通讯作者：
Sherman, Steven I.
影响因子：
19.7
作者：
Kwak, Jin Young;Han, Kyung Hwa;Kim, Eun-Kyung
通讯作者：
Kim, Eun-Kyung
影响因子：
9.6
作者：
Tan, MP;Agarwal, G;Delbridge, LW
通讯作者：
Delbridge, LW