Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma.
Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma.
复制标题
乳头状甲状腺微核瘤患者的宫颈淋巴转移风险因素的临床分析。
DOI：
10.1007/s40618-018-0908-y
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发表时间：
2019-03
影响因子：
5.4
通讯作者：
Luo D
中科院分区：
文献类型：
--
作者：
Luo Y;Zhao Y;Chen K;Shen J;Shi J;Lu S;Lei J;Li Z;Luo D
淋巴结转移（LNM）是影响甲状腺微小乳头状癌（PTMC）预后的重要因素。本研究试图找出PTMC LNM的临床病理因素。收集1031例PTMC患者的临床病理资料进行分析。采用单因素和多因素分析确定与颈淋巴结转移相关的危险因素。采用ROC曲线分析确定单侧肺叶多病灶最大直径之和的理想临界点。PTMC患者LNM、中央淋巴结转移（CLNM）和外侧淋巴结转移（LLNM）的概率分别为35.6%、33.7%和5.6%。此外，1.9%的PTMC仅有LLNM。男性，年龄≤ 40岁，肿瘤最大直径≥ 5 mm，多灶性，回声分布不均匀，单侧肺叶多灶性最大直径之和≥ 8. 5 mm，肿瘤位于下极部位易发生CLNM。超声混合回声，多灶最大直径之和≥ 10.75 mm，上极位置的肿瘤极易发生LLNM。T3易发生LLNM或跳过LLNM。根据PTMC的临床病理特点，应正确评估颈部淋巴结，指导手术治疗。
Lymph node metastasis (LNM) is a vital prognosis factor in patients with papillary thyroid microcarcinoma (PTMC). The study tried to identify clinicopathological factors for LNM of PTMC. The clinicopathological data of 1031 patients with PTMC were extracted and analyzed. Univariate and multivariate analyses were used to identify risk factors associated with cervical lymph node metastasis. ROC analysis was used to determine the ideal critical points of the sum of the maximum diameter of multifocal in a unilateral lobe. The probability of LNM, central lymph node metastasis (CLNM) and lateral lymph node metastasis(LLNM)of PTMC patients were 35.6, 33.7 and 5.6%, respectively. In addition, 1.9% PTMC had LLNM only. Male, age ≤ 40 years, tumor largest diameter ≥ 5 mm, multifocal, non-uniform echoic distribution, the sum of the maximum diameter of multifocal in a unilateral lobe ≥ 8.5 mm, tumors in the lower pole location were prone to CLNM. Ultrasound mix-echo, the sum of the maximum diameter of the multifocal ≥ 10.75 mm, tumors in the upper pole location were extremely prone to LLNM. T3 were prone to LLNM or skip LLNM. According to the clinicopathological characteristics of PTMC, the cervical lymph nodes should be correctly evaluated to guide the surgical treatment.
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DOI：
10.1002/hed.23333
发表时间：
2014-04-01
影响因子：
2.9
作者：
Vasileiadis, Ioannis;Karatzas, Theodore;Kouraklis, Gregory
通讯作者：
Kouraklis, Gregory
DOI：
10.1002/hed.21979
发表时间：
2012-12-01
影响因子：
2.9
作者：
Wu, Gaosong;Chang, Xiaofei;Koch, Wayne M.
通讯作者：
Koch, Wayne M.
甲状腺微小乳头状癌颈部淋巴结转移的危险因素：一项针对 1066 名患者的研究
影响因子：
5.8
作者：
Zhang, Ling;Wei, Wen-jun;Wu, Yi
通讯作者：
Wu, Yi
影响因子：
1.2
作者：
Lu, Zhong-Zhi;Zhang, Yan;Li, Li
通讯作者：
Li, Li
影响因子：
5.4
作者：
Sapuppo, G.;Palermo, F.;Pellegriti, G.
通讯作者：
Pellegriti, G.