15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity
15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity
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胃癌中 15-PGDH 的表达：在抗肿瘤免疫中的潜在作用
DOI：
10.2147/cmar.s245726
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发表时间：
2020
影响因子：
3.3
通讯作者：
Yongqi Liu
中科院分区：
文献类型：
--
作者：
Yaling Li;Junjie Li;Juanjuan Dong;Lei Zhang;Dongling Liu;Jianzheng He;Yali She;Chengxu Ma;Yongqi Liu
前言：宿主免疫在肿瘤的发生，包括肿瘤的侵袭和转移中起重要作用。然而，其确切的潜在机制仍有待探索。15-前列腺素脱氢酶在前列腺素降解过程中起关键作用，是胃癌(GC)发生发展过程中的重要炎症介质。材料与方法应用免疫组织化学方法检测92例胃癌及相应癌旁非肿瘤组织中15-PGDH的表达。结果15-Pgdh在胃癌组织中的表达显著低于癌旁组织(P<；0.001)，且与胃癌分化程度(P=0.043)和淋巴结转移(P=0.046)呈负相关。而在低分化胃癌组织中，FOXP3的表达增加(P=0.001)。Kaplan-Meier分析显示，15-前列腺素脱氢酶低表达(对数等级检验，P=0.007)和FOXP3高表达(对数等级检验，P=0.009)的胃癌患者的总生存期(OS)短于15-前列腺素脱氢酶高表达和FOXP3低表达的患者。OS与肿瘤病理转移分期相关(Log ranch检验，P=0.014)。此外，经COX比例风险回归分析，15-前列腺素脱氢酶的表达[危险比(HR)：0.605(0.440-0.833)；P=0.002]被确定为OS的独立因素。结论15-PGDH可能通过调节FOXP3+Treg细胞发挥抗肿瘤免疫作用。这一发现对于确定治疗GC的靶点是有用的。
Introduction Host immunity plays a vital role in tumorigenesis, including in tumor invasion and metastasis. However, the precise underlying mechanism remains to be explored. The enzyme 15-PGDH, which plays a key role in prostaglandin degradation, is a critical inflammatory mediator in gastric cancer (GC) tumorigenesis. Materials and Methods Immunohistochemistry was performed to determine 15-PGDH expression in GC and the corresponding adjacent non-neoplastic tissues (n=92). Results The expression of 15-PGDH in GC tissues was significantly lower than that in paracancerous tissues (P<0.001) and found to correspond inversely with GC differentiation (P=0.043) and lymph node metastasis (P=0.046). In contrast, FOXP3 expression was increased in poorly differentiated GC tissues (P=0.001). Kaplan–Meier analysis revealed that GC patients with low expression of 15-PGDH (Log rank test, P=0.007) and high expression of FOXP3 (Log rank test, P=0.009) had shorter overall survival (OS) than those with high 15-PGDH and low FOXP3 expression. OS was also correlated with pathological tumor-node-metastasis stage (Log rank test, P=0.014). Furthermore, using Cox proportional hazard regression, 15-PGDH expression [hazard ratio (HR): 0.605 (0.440–0.833); P=0.002] was identified as an independent factor for OS. Conclusion Our data suggest that 15-PGDH may contribute to anti-tumor immunity by regulating FOXP3+ Treg cells. The findings are useful for the identification of therapeutic targets for the management of GC.
影响因子：
16.8
作者：
Savage PA;Malchow S;Leventhal DS
通讯作者：
Leventhal DS
影响因子：
14.5
作者：
Whiteside TL
通讯作者：
Whiteside TL