Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression.
Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression.
复制标题
DOI：
10.1021/acschemneuro.8b00134
复制
发表时间：
2018-07-18
影响因子：
5
通讯作者：
Olson DE
中科院分区：
文献类型：
--
作者：
Cameron LP;Benson CJ;Dunlap LE;Olson DE
抑郁症和焦虑症是使人衰弱的疾病，给社会造成了巨大的经济代价。传统的抗抑郁药通常需要几周到几个月的时间才能对情绪产生积极影响，对大约30%的人无效。诸如氯胺酮（一种能够产生幻觉的解离性麻醉剂）和死藤水（ayahuasca）等替代药物，由于其快速起效的性质和对治疗耐药人群的有效性，已经显示出巨大的希望。在这里，我们研究了N，N-二甲基色胺（DMT）的作用，死水的主要致幻成分，在啮齿动物行为分析中与焦虑和抑郁有关，使用成年，雄性，Sprague-Dawley大鼠。我们发现，虽然DMT在这些范例中引发了最初的焦虑反应，但其长期效应倾向于通过促进线索恐惧记忆的消失来减少焦虑。此外，DMT减少了强迫游泳测试中的不动，这是许多抗抑郁药引起的典型行为反应。我们的研究结果表明，DMT在啮齿类动物中产生抗抑郁和抗焦虑的行为作用，值得进一步研究死藤水和经典迷幻药作为抑郁症和创伤后应激障碍的治疗方法。
Depression and anxiety disorders are debilitating diseases resulting in substantial economic costs to society. Traditional antidepressants often take weeks to months to positively affect mood and are ineffective for about 30% of the population. Alternatives, such as ketamine, a dissociative anesthetic capable of producing hallucinations, and the psychoactive tisane ayahuasca have shown great promise due to their fast-acting nature and effectiveness in treatment-resistant populations. Here, we investigate the effects of N,N-dimethyltryptamine (DMT), the principle hallucinogenic component of ayahuasca, in rodent behavioral assays relevant to anxiety and depression using adult, male, Sprague-Dawley rats. We find that while DMT elicits initial anxiogenic responses in several of these paradigms, its long-lasting effects tend to reduce anxiety by facilitating the extinction of cued fear memory. Furthermore, DMT reduces immobility in the forced swim test, which is a characteristic behavioral response induced by many antidepressants. Our results demonstrate that DMT produces antidepressant and anxiolytic behavioral effects in rodents, warranting further investigation of ayahuasca and classical psychedelics as treatments for depression and post-traumatic stress disorder.
登录
查看更多内容
影响因子：
4.6
作者：
Dakic V;Minardi Nascimento J;Costa Sartore R;Maciel RM;de Araujo DB;Ribeiro S;Martins-de-Souza D;Rehen SK
通讯作者：
Rehen SK
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
3.6
作者：
Appel, JB;West, WB;Pechersky, K
通讯作者：
Pechersky, K
DOI：
10.4088/jcp.09m05327blu
发表时间：
2010-12
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
DiazGranados N;Ibrahim LA;Brutsche NE;Ameli R;Henter ID;Luckenbaugh DA;Machado-Vieira R;Zarate CA Jr
通讯作者：
Zarate CA Jr