Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy.
Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy.
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DOI：
10.1016/j.semnephrol.2012.07.009
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发表时间：
2012-09
影响因子：
3.3
通讯作者：
Humphreys, Benjamin D.
中科院分区：
文献类型：
--
作者：
Humphreys, Benjamin D.
周细胞是一组异质的广泛分支的细胞，位于微血管中，它们与内皮细胞进行局灶性接触。周细胞具有稳定血管、调节血管张力、合成基质、参与修复和作为祖细胞等功能。最近的工作强调了周细胞和周细胞样细胞在纤维化中的作用，慢性损伤触发周细胞增殖和分化为胶原分泌、收缩的肌成纤维细胞，并从血管迁移，导致微血管稀疏。本文综述了肾周细胞和血管周围成纤维细胞的发育起源，讨论了I型糖尿病肾病中周细胞向肌成纤维细胞的转化，并描述了周细胞向肌成纤维细胞分化的调控作为治疗糖尿病肾病的靶点。
Pericytes are a heterogeneous group of extensively branched cells located in microvessels where they make focal contacts with endothelium. Pericytes stabilize blood vessels, regulate vascular tone, synthesize matrix, participate in repair and serve as progenitor cells, among other functions. Recent work has highlighted the role of pericytes and pericyte-like cells in fibrosis, where chronic injury triggers pericyte proliferation and differentiation into collagen-secretory, contractile myofibroblasts with migration away from vessels, causing microvascular rarefaction. In this review I summarize the developmental origins of kidney pericytes and perivascular fibroblasts, discuss pericyte to myofibroblast transition in type I diabetic nephropathy and describe the regulation of pericyte differentiation into myofibroblasts as a therapeutic target for treatment of diabetic nephropathy.
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影响因子：
3
作者：
Grgic, Ivica;Duffield, Jeremy S.;Humphreys, Benjamin D.
通讯作者：
Humphreys, Benjamin D.
DOI：
10.1152/ajpgi.00292.2009
发表时间：
2009-12-01
影响因子：
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作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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