Clinical features, comparative imaging findings, treatment, and outcome in dogs with discospondylitis: A multi-institutional retrospective study.
Clinical features, comparative imaging findings, treatment, and outcome in dogs with discospondylitis: A multi-institutional retrospective study.
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DOI：
10.1111/jvim.16785
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发表时间：
2023-07
影响因子：
2.6
通讯作者：
Cridge, Harry
中科院分区：
文献类型：
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作者：
Van Hoof, Cassie;Davis, Nicole A.;Carrera-Justiz, Sheila;Kahn, Alisha D.;De Decker, Steven;Grapes, Nicholas J.;Beasley, Michaela;Du, John;Pancotto, Theresa E.;Sunol, Anna;Shinn, Richard;DeCicco, Barry;Burkland, Erica;Cridge, Harry
关于狗患脊髓炎的最新数据有限。(I)描述犬椎间盘脊柱炎的信号、临床和影像表现、病因、治疗和结果；(Ii)确定X线片、CT和MRI关于腰椎炎的存在及其位置的诊断一致性；以及(Iii)确定复发和进行性神经恶化的危险因素。386只狗。多机构的回顾性研究。从病历中提取的数据包括：信号、临床和检查结果、诊断结果、治疗、并发症和结果。记录潜在危险因素。将品种分布与对照组进行比较。通过Cohen‘s kappa统计量评估不同成像方式之间的一致性。其他分析是在分类数据上进行的，使用卡方和费舍尔精确检验的交叉表。雄犬比例过高(236/386只)。L7-S1(97/386只犬)是最常见的部位。葡萄球菌占多数(23/38例血培养阳性)。在腰椎炎的证据方面，X线片和CT之间有较好的一致性(κ = 0.22)，但X线片和MRI之间的一致性较差(κ = 0.05)。关于疾病的位置，两种成像方式之间有很好的一致性。创伤与复发风险增加相关(P = .01，OR：9.0，95%CI：2.2-37.0)。既往接受类固醇治疗与进行性神经功能障碍的风险增加有关(P = .04，OR：4.7，95%CI：1.2-18.6)。患有腰椎炎的狗的X线片和MRI结果可能不一致。既往创伤和皮质类固醇可能分别与复发和进行性神经功能障碍有关。
Limited recent data exists regarding discospondylitis in dogs. (i) Describe the signalment, clinical and imaging findings, etiologic agents, treatment, and outcome of dogs with discospondylitis, (ii) determine diagnostic agreement between radiographs, CT, and MRI with regard to the presence of discospondylitis and its location, and (iii) determine risk factors for relapse and progressive neurological deterioration. Three hundred eighty‐six dogs. Multi‐institutional retrospective study. Data extracted from medical records were: signalment, clinical and examination findings, diagnostic results, treatments, complications, and outcome. Potential risk factors were recorded. Breed distribution was compared to a control group. Agreement between imaging modalities was assessed via Cohen's kappa statistic. Other analyses were performed on categorical data, using cross tabulations with chi‐squared and Fisher's exact tests. Male dogs were overrepresented (236/386 dogs). L7‐S1 (97/386 dogs) was the most common site. Staphylococcus species (23/38 positive blood cultures) were prevalent. There was a fair agreement (κ = 0.22) between radiographs and CT, but a poor agreement (κ = 0.05) between radiographs and MRI with regard to evidence of discospondylitis. There was good agreement between imaging modalities regarding location of disease. Trauma was associated with an increased risk of relapse (P = .01, OR: 9.0, 95% CI: 2.2‐37.0). Prior steroid therapy was associated with an increased risk of progressive neurological dysfunction (P = .04, OR: 4.7, 95% CI: 1.2‐18.6). Radiograph and MRI results could be discrepant in dogs with discospondylitis. Prior trauma and corticosteroids could be associated with relapse and progressive neurological dysfunction, respectively.
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影响因子：
3.2
作者：
Long, Christina;Burgers, Elisabeth;Copple, Christina;Stainback, Laura;Packer, Rebecca A.;Kopf, Kelli;Schmidt, Jessica;Emch, Samantha;Windsor, Rebecca
通讯作者：
Windsor, Rebecca
影响因子：
1.7
作者：
Gonzalo-Orden, JM;Alt贸naga, JR;Gonzalo, JM
通讯作者：
Gonzalo, JM
影响因子：
2.6
作者：
Schultz, R. M.;Johnson, E. G.;Sykes, J. E.
通讯作者：
Sykes, J. E.
影响因子：
1.7
作者：
Carrera, Ines;Sullivan, Martin;Goncalves, Rita
通讯作者：
Goncalves, Rita
影响因子：
3.2
作者：
通讯作者：
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