Translational Medicine of Stem Cells: Central Nervous System Regeneration and Modeling Neurological Diseases
Translational Medicine of Stem Cells: Central Nervous System Regeneration and Modeling Neurological Diseases
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干细胞转化医学：中枢神经系统再生和神经系统疾病建模
DOI：
10.1007/978-4-431-54306-0_5
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
H. Okano
中科院分区：
文献类型：
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作者：
H. Okano
我们一直在进行受损中枢神经系统再生的研究，其中包括（i）受损神经元轴突的再生，（ii）补充丢失的神经细胞，以及（iii）恢复丢失的神经功能。特别是，我们研究了治疗脊髓损伤的细胞疗法。考虑到与胎儿细胞和胚胎干细胞相关的伦理问题，人们对涉及诱导多能干（iPS）细胞的干细胞技术越来越感兴趣。在这里，我们想介绍一下我们在iPS细胞治疗方面取得的成果。除了细胞治疗应用之外，iPS 细胞技术还为研究各种疾病的病理生理学提供了多功能工具。事实上，疾病模型小鼠并不总能重现人类疾病的病理生理学。然而，iPS细胞技术可以提供一些解决方案，因为可以获得不同发育阶段的神经细胞以及与患者具有相同遗传信息的多种细胞以进行进一步研究。通过这些调查，我与包括制药公司在内的生命科学行业进行了多次合作，并获得了各种专利。这里将讨论这些成就的一些例子。
We have been conducting research on regeneration of the damaged central nervous system, which includes (i) regrowth of the disrupted neuronal axons, (ii) replenishment of lost neural cells, and (iii) recovery of lost neural functions. In particular, we have investigated cell therapy for treating spinal cord injury. Considering the ethical issues related to fetal cells and embryonic stem cells, there is increasing interest in stem cell technology involving induced pluripotent stem (iPS) cells. Here, we wish to introduce our achievements in iPS cell-based therapy. In addition to their application for cell therapy, iPS cell technologies provide versatile tools for investigation of the pathophysiology of various diseases. Indeed, disease model mice do not always recapitulate the pathophysiology of human diseases. However, iPS cell technology can provide some solutions because neural cells at various developmental stages and a wide variety of cells with the same genetic information as that of patients can be obtained for further investigation. Through these investigations, I have had numerous collaborations with life science industries, including pharmaceutical companies, and generated various patents. Some examples of these achievements will be discussed here.
DOI：
10.1073/pnas.1116738109
发表时间：
2012-08-21
影响因子：
11.1
作者：
Mchedlishvili, Levan;Mazurov, Vladimir;Tanaka, Elly M.
通讯作者：
Tanaka, Elly M.