Ventral neuroblasts and the heartless FGF receptor are required for muscle founder cell specification in Drosophila.

Ventral neuroblasts and the heartless FGF receptor are required for muscle founder cell specification in Drosophila.
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腹神经母细胞和无情的 FGF 受体是果蝇肌肉创建细胞规范化所必需的。

DOI:
10.1038/sj.onc.1203081
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发表时间:
1999
期刊:
影响因子:
8
通讯作者:
Gajewski,K
Gajewski,K
中科院分区:
医学1区
文献类型:
--
作者:
Schulz,RA;Gajewski,K

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Muscle founder cells are uniquely specified cells that fuse with neighboring myoblasts to generate the complex pattern of body wall muscles in the Drosophila embryo. We have investigated the positional specification of founder cells for ventral oblique muscles, marked by the restricted expression of tinman RNA and the activity of a D-mef2 enhancer. The formation of these ventral myoblasts requires the function of the Heartless FGF receptor in the mesoderm and the presence of ventral neuroblasts in the central nervous system. Overproduction of ventral neuroblasts due to the forced expression of the homeodomain protein Vnd leads to increased numbers of founder cells. These results suggest the use of a neuroectoderm-to-mesoderm signaling pathway in the specification of ventral muscle precursors.
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