Fibronectin-cleaving activity in bronchial secretions of patients with cystic fibrosis.
Fibronectin-cleaving activity in bronchial secretions of patients with cystic fibrosis.
复制标题
囊性纤维化患者支气管分泌物中的纤连蛋白裂解活性。
DOI：
--
复制
发表时间：
1988
影响因子：
6.4
通讯作者：
H. Schnebli
中科院分区：
文献类型：
--
作者：
Susanne Suter;Urs B. Schaad;J. Morgenthaler;Isabelle Chevallier;H. Schnebli
In cystic fibrosis, colonization of the airways with Pseudomonas aeruginosa follows colonization with Staphylococcus aureus and is related to accelerated deterioration of pulmonary function. Because P. aeruginosa adheres better to cell surfaces devoid of fibronectin, we searched for fibronectin-cleaving activity in bronchial secretions and saliva from 24 patients with cystic fibrosis who were followed up for 4.5 y and from two control groups. Proteolytic activity against 125I-labeled fibronectin was continuously present in cystic fibrosis bronchial secretions; significantly higher fibronectin-cleaving activity was found in older vs. younger patients, in patients with advanced disease stages determined by a five-stage scoring system, and in those colonized with P. aeruginosa. The fibronectin-cleaving activity was due to neutrophil elastase and cathepsin G. Cystic fibrosis bronchial secretions had proteolytic activity against surface fibronectin of airway mucosal cells. Thus fibronectin-cleaving activity of bronchial secretions rather than of saliva may favor P. aeruginosa colonization of the upper respiratory tract in individuals with cystic fibrosis.
登录
查看更多内容
囊性纤维化肺部病理学的定量方面。
DOI：
10.1164/arrd.1986.134.2.290
发表时间：
1986
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Sobonya,RE;Taussig,LM
通讯作者：
Taussig,LM
唾液蛋白酶活性在革兰氏阴性杆菌与哺乳动物口腔上皮细胞体内粘附中的作用。
DOI：
10.1172/jci110395
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Woods,DE;Straus,DC;JohansonJr,WG;Bass,JA
通讯作者：
Bass,JA
术后患者唾液弹性蛋白酶增加先于革兰氏阴性杆菌定植。
DOI：
10.1164/arrd.1987.135.3.671
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
DalNogare,AR;Toews,GB;Pierce,AK
通讯作者：
Pierce,AK
依从性在囊性纤维化患者铜绿假单胞菌肺部感染发病机制中的作用。
影响因子：
3.1
作者：
Woods,DE;Bass,JA;JohansonJr,WG;Straus,DC
通讯作者：
Straus,DC
纤连蛋白在防止铜绿假单胞菌粘附到口腔细胞中的作用。
DOI：
10.1093/infdis/143.6.784
发表时间：
1981
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Woods,DE;Straus,DC;JohansonJr,WG;Bass,JA
通讯作者：
Bass,JA