Dynamic Regulation of Circulating microRNAs During Acute Exercise and Long-Term Exercise Training in Basketball Athletes.
Dynamic Regulation of Circulating microRNAs During Acute Exercise and Long-Term Exercise Training in Basketball Athletes.
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篮球运动员急性运动和长期运动训练中循环microRNA的动态调控
DOI：
10.3389/fphys.2018.00282
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发表时间：
2018
影响因子：
4
通讯作者：
Bei Y
中科院分区：
文献类型：
--
作者：
Li Y;Yao M;Zhou Q;Cheng Y;Che L;Xu J;Xiao J;Shen Z;Bei Y
越来越多的证据表明，体育锻炼对人体健康的有益影响，这取决于强度，训练时间，运动类型，环境因素和个人健康状况。传统的生物标志物提供了有限的洞察运动诱导的适应性过程。循环microRNA（miRNAs，miRs）在急性力竭运动和持续划船、跑步和骑自行车运动中受到动态调节。然而，循环中的miRNAs对长期篮球运动的反应仍然是未知的。在这里，我们招募了10名篮球运动员，他们将参加为期3个月的篮球赛季。具体而言，在基线、急性力竭运动后立即和竞技男子篮球运动员3个月篮球比赛后分析参与血管生成、炎症并在肌肉和/或心脏组织中富集的循环miRNA。3个月篮球运动后，循环miR-208 b减少，miR-221增加，而循环miR-221，miR-21，miR-146 a和miR-210在急性运动后减少。miR-146 a的变化（基线与急性运动后）与心脏标志物CKMB的基线水平和炎症标志物Hs-CRP的变化（基线与急性运动后）呈线性相关。此外，miR-208 b变化（基线与长期运动后）与AT VO 2（基线）之间观察到线性相关性。miR-221的变化（基线与长期运动后）与AT VO 2、峰值负荷和CK（3个月篮球比赛后）显著相关。虽然还需要进一步的研究，但目前的研究结果为将循环miRNA定义为生物标志物并表明其在长期运动训练诱导的心血管适应中的生理作用奠定了基础。
Emerging evidence indicates the beneficial effects of physical exercise on human health, which depends on the intensity, training time, exercise type, environmental factors, and the personal health status. Conventional biomarkers provide limited insight into the exercise-induced adaptive processes. Circulating microRNAs (miRNAs, miRs) are dynamically regulated in response to acute exhaustive exercise and sustained rowing, running and cycling exercises. However, circulating miRNAs in response to long-term basketball exercise remains unknown. Here, we enrolled 10 basketball athletes who will attend a basketball season for 3 months. Specifically, circulating miRNAs which were involved in angiogenesis, inflammation and enriched in muscle and/or cardiac tissues were analyzed at baseline, immediately following acute exhaustive exercise and after 3-month basketball matches in competitive male basketball athletes. Circulating miR-208b was decreased and miR-221 was increased after 3-month basketball exercise, while circulating miR-221, miR-21, miR-146a, and miR-210 were reduced at post-acute exercise. The change of miR-146a (baseline vs. post-acute exercise) showed linear correlations with baseline levels of cardiac marker CKMB and the changes of inflammation marker Hs-CRP (baseline vs. post-acute exercise). Besides, linear correlation was observed between miR-208b changes (baseline vs. after long-term exercise) and AT VO2 (baseline). The changes of miR-221 (baseline vs. after long-term exercise) were significantly correlated with AT VO2, peak work load and CK (after 3-month basketball matches). Although further studies are needed, present findings set the stage for defining circulating miRNAs as biomarkers and suggesting their physiological roles in long-term exercise training induced cardiovascular adaptation.
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从全血中分离的富含肌肉的microRNA受运动调节，是心肺适应性的潜在生物标志物。
影响因子：
3.7
作者：
Denham J;Prestes PR
通讯作者：
Prestes PR
影响因子：
3.7
作者：
Cardinali B;Castellani L;Fasanaro P;Basso A;Alemà S;Martelli F;Falcone G
通讯作者：
Falcone G
影响因子：
37.8
作者：
Hu S;Huang M;Li Z;Jia F;Ghosh Z;Lijkwan MA;Fasanaro P;Sun N;Wang X;Martelli F;Robbins RC;Wu JC
通讯作者：
Wu JC
影响因子：
39.3
作者：
Corsten, Maarten;Heggermont, Ward;Heymans, Stephane
通讯作者：
Heymans, Stephane
影响因子：
11.1
作者：
Cheng, Henry S.;Sivachandran, Nirojini;Lau, Andrew;Boudreau, Emilie;Zhao, Jimmy L.;Baltimore, David;Delgado-Olguin, Paul;Cybulsky, Myron I.;Fish, Jason E.
通讯作者：
Fish, Jason E.