The multiple sclerosis prodrome.
The multiple sclerosis prodrome.
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DOI：
10.1038/s41582-021-00519-3
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Tremlett H
中科院分区：
文献类型：
--
作者：
Makhani N;Tremlett H
前驱症状是在疾病的典型症状发作之前出现的一组早期体征、症状或其他发现。前驱期在几种神经系统和炎症性疾病中得到了很好的认识，但在多发性硬化症（MS）中前驱症状的可能性直到过去几年才受到相对较少的关注。在这方面，我们总结了目前已知的MS前驱症状，包括其可能的持续时间，临床特征和潜在的生物标志物。我们还考虑了从其他疾病前驱期的知识和研究中可以学到什么见解和教训。更好地了解MS前驱症状可能具有深远的临床意义，因为它可以使MS的早期识别和早期开始治疗，降低复发率和长期残疾。对MS前驱症状的了解也可能影响对MS病因的研究，并且必须根据MS前驱症状重新评估推定的风险因素。最后，我们概述了主要的知识差距，并提出未来的举措。
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of typical symptoms of a disease. Prodromal phases are well recognized in several neurological and inflammatory diseases, but the possibility of a prodrome in multiple sclerosis (MS) has received relatively little attention until the past few years. In this Perspective, we summarize what is currently known about the MS prodrome, including its possible duration, clinical features and potential biomarkers. We also consider what insights and lessons can be learned from knowledge of and research into the prodromal phases of other diseases. A better understanding of the MS prodrome could have profound clinical implications as it could enable earlier recognition of MS and earlier initiation of treatments that reduce relapse rates and long-term disability. Knowledge of the MS prodrome could also affect research into the causes of MS, and putative risk factors must be re-evaluated in light of the MS prodrome. We conclude by outlining the major knowledge gaps and propose future initiatives.
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影响因子：
29
作者：
Bjornevik, Kjetil;Munger, Kassandra L.;Ascherio, Alberto
通讯作者：
Ascherio, Alberto
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
影响因子：
11
作者：
Gout, O.;Lebrun-Frenay, C.;Allouche, S.
通讯作者：
Allouche, S.
影响因子：
11.2
作者：
De Stefano, N;Cocco, E;Marrosu, MG
通讯作者：
Marrosu, MG
DOI：
10.1177/1352458508101933
发表时间：
2009-05-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Chitnis, T.;Glanz, B.;Healy, B.
通讯作者：
Healy, B.