The contribution of direct TLR signaling to T cell responses.
The contribution of direct TLR signaling to T cell responses.
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DOI：
10.1007/s12026-009-8113-x
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发表时间：
2009
影响因子：
4.4
通讯作者：
Turka LA
中科院分区：
文献类型：
--
作者：
Rahman AH;Taylor DK;Turka LA
众所周知，Toll样受体(TLRs)在先天免疫应答的产生中起着关键作用，因此在随后的适应性T细胞应答的启动中也起着重要的间接作用。然而，T细胞也表达某些TLR，我们主要关注T细胞中直接TLR信号的生理重要性。TLRs可以作为共刺激受体，补充TCR诱导的信号，促进效应器T细胞的增殖、存活和细胞因子的产生。我们还发现，在体内感染过程中，T细胞中的TLR信号通路是抗原特异性T细胞有效克隆增殖所必需的。因此，TLRs在T细胞介导的免疫中的重要性既反映了T细胞的外在成分，也反映了T细胞的内在成分，这就需要重新考虑将生殖系编码的模式识别限制在天然免疫系统细胞的教条。
It is well established that Toll-like receptors (TLRs) play a critical role in the generation of innate immune responses and thereby also play an important, indirect role in the initiation of subsequent adaptive T cell responses. However, T cells also express certain TLRs, and we have focused on the physiological importance of direct TLR signaling in T cells. TLRs can function as co-stimulatory receptors that complement TCR-induced signals to enhance effector T cell proliferation, survival and cytokine production. We also found that TLR signaling pathways in T cells are required for the effective clonal expansion of antigen-specific T cells during infection in vivo. Thus, the importance of TLRs in T cell-mediated immunity reflects both T cell-extrinsic and T cell-intrinsic components, which warrants a reconsideration of the dogma that restricts germ-line encoded pattern recognition to cells of the innate immune system.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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DOI：
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