B7-H3 is overexpressed in patients suffering osteosarcoma and associated with tumor aggressiveness and metastasis.
B7-H3 is overexpressed in patients suffering osteosarcoma and associated with tumor aggressiveness and metastasis.
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DOI：
10.1371/journal.pone.0070689
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Wang L;Zhang Q;Chen W;Shan B;Ding Y;Zhang G;Cao N;Liu L;Zhang Y
B7-H3是共刺激分子B7家族的一员，广泛表达于多种肿瘤组织中，在获得性免疫应答中发挥重要作用。然而，B7-H3在骨肉瘤中的作用仍然未知。在这项研究中，我们使用免疫组化分析B7-H3在61例原发性骨肉瘤组织与病例匹配的相邻正常组织，37例骨软骨瘤和20例骨纤维异常增殖症组织中的表达。91.8%（56/61）的骨肉瘤病变中B7-H3表达，骨肉瘤中B7-H3表达强度与邻近正常组织、骨软骨瘤和骨纤维异常增殖症组织相比明显增强（p<0.001）。高肿瘤B7-H3水平的患者比低肿瘤B7-H3水平的患者具有显著更短的生存时间和复发时间（p<0.001）。此外，肿瘤B7-H3表达与肿瘤浸润性CD 8 + T细胞的数量呈负相关（p<0.05）。在体外，B7-H3表达的增加促进骨肉瘤细胞的侵袭，至少部分通过上调基质金属蛋白酶-2（MMP-2）。总之，我们的研究提供了骨肉瘤细胞中B7-H3表达作为控制肿瘤免疫和侵袭性恶性肿瘤的潜在机制的第一个证据，并且其与患者的生存和转移相关。
B7-H3 is a member of the B7-family of co-stimulatory molecules, which has been shown to be broadly expressed in various tumor tissues, and which plays an important role in adaptive immune responses. The role of B7-H3 in osteosarcoma, however, remains unknown. In this study we used immunohistochemistry to analyze B7-H3 expression in 61 primary osteosarcoma tissues with case-matched adjacent normal tissues, and 37 osteochondroma and 20 bone fibrous dysplasia tissues. B7-H3 expression was expressed in 91.8% (56/61) of the osteosarcoma lesions, and the intensity of B7-H3 expression in osteosarcoma was significantly increased compared with adjacent normal tissues, osteochondroma and bone fibrous dysplasia tissues (p<0.001). Patients with high tumor B7-H3 levels had a significantly shorter survival time and recurrence time than patients with low tumor B7-H3 levels (p<0.001). Moreover, tumor B7-H3 expression inversely correlated with the number of tumor-infiltrating CD8+ T cells (p<0.05). In vitro, increasing expression of B7-H3 promotes osteosarcoma cell invasion, at least in part by upregulating matrix metalloproteinase-2 (MMP-2). In conclusion, our study provides the first evidence of B7-H3 expression in osteosarcoma cells as a potential mechanism controlling tumor immunity and invasive malignancy, and which is correlated with patients’ survival and metastasis.
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影响因子：
4.8
作者：
Fromigue, Olivia;Hamidouche, Zahia;Marie, Pierre J.
通讯作者：
Marie, Pierre J.
DOI：
10.1073/pnas.0405025101
发表时间：
2004-08-24
影响因子：
11.1
作者：
Castriconi, R;Dondero, A;Bottino, C
通讯作者：
Bottino, C
影响因子：
20.4
作者：
Schneider, Thomas;Hoffmann, Hans;Mahnke, Karsten
通讯作者：
Mahnke, Karsten
影响因子：
50.5
作者：
Ritter, J.;Bielack, S. S.
通讯作者：
Bielack, S. S.
DOI：
10.1084/jem.20090681
发表时间：
2009-07-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brandt CS;Baratin M;Yi EC;Kennedy J;Gao Z;Fox B;Haldeman B;Ostrander CD;Kaifu T;Chabannon C;Moretta A;West R;Xu W;Vivier E;Levin SD
通讯作者：
Levin SD