The role of intolerance of uncertainty in the acquisition and extinction of reward
The role of intolerance of uncertainty in the acquisition and extinction of reward
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不能容忍不确定性在奖励的获得和消失中的作用
DOI：
10.1101/2020.05.18.101212
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Morriss J
中科院分区：
文献类型：
--
作者：
Morriss J
在自我报告的不确定性不容忍（IU）中得分高的人往往会发现不确定性焦虑。IU与中断的威胁灭绝可靠相关。然而，目前还不清楚IU是否与其他不具威胁性的唤醒刺激（即，奖励）。我们解决了这个问题，进行了巴甫洛夫奖励条件反射任务与收购和灭绝的培训阶段（n= 58）。在巴甫洛夫奖励条件反射任务中，我们记录了喜欢等级、皮肤电导反应（SCR）和皱眉肌活动（即，眉毛肌肉指示或消极和积极的影响）学习奖励（CS+）和中性（CS-）线索。奖励获取和灭绝训练的典型模式被观察到喜欢评级。有证据表明，条件反射在消退训练阶段，但不是收购培训阶段。然而，没有证据的条件反射，无论是收购或灭绝的培训阶段，观察皱眉肌。IU与获得或消退训练阶段的任何措施无关。综上所述，这些结果表明，目前的巴甫洛夫奖励条件反射任务不足以引发可靠的条件性奖励反应，因此，需要进一步研究优化的奖励条件反射设计，以测试在奖励消退期间是否发生IU相关的缺陷。
Individuals, who score high in self‐reported intolerance of uncertainty (IU), tend to find uncertainty anxiety‐provoking. IU has been reliably associated with disrupted threat extinction. However, it is unclear whether IU would be related to disrupted extinction to other arousing stimuli that are not threatening (i.e., rewarding). We addressed this question by conducting a Pavlovian reward conditioning task with acquisition and extinction training phases (n= 58). In the Pavlovian reward conditioning task, we recorded liking ratings, skin conductance response (SCR), and corrugator supercilii activity (i.e., brow muscle indicative or negative and positive affect) to learned reward (CS+) and neutral (CS−) cues. Typical patterns of reward acquisition and extinction training were observed for liking ratings. There was evidence for conditioning in SCR during the extinction training phase but not the acquisition training phase. However, no evidence of conditioning in either the acquisition or extinction training phase was observed for the corrugator supercilii. IU was not related to any measures during the acquisition or extinction training phases. Taken together, these results suggest that the current Pavlovian reward conditioning task was not sufficient for eliciting a reliable conditioned reward response, and therefore, further research with optimized reward conditioning designs are required to test whether IU‐related deficits occur during the extinction of reward.
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