The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits.
The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits.
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DOI：
10.1016/j.neuron.2011.04.007
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发表时间：
2011-04-28
期刊：
影响因子：
16.2
通讯作者：
Nicoll RA
中科院分区：
文献类型：
--
作者：
Jackson AC;Nicoll RA
整个中枢神经系统中的快速，兴奋性突触信号传导是离子型谷氨酸受体（iGlurs）。经过多年的深入研究，我们对iGlurs的图片已经从想象它们在突触后膜中伴随着伴侣而发展成为动态超分子信号传导复合物的枢纽，与不断扩大的其他蛋白质相互作用，这些蛋白质会调节其运输，脚手架，脚手架，稳定，信号，信号，信号，信号和转移。特别是，跨膜AMPA受体调节蛋白（TARPS）的发现是AMPA受体的辅助亚基，它们是其贩运，门控和药理学的关键决定因素，它改变了我们考虑iGlur功能的方式。最近，已经发现了许多新型的跨膜蛋白，它们也可以用作Iglur辅助蛋白。在这里，我们回顾了我们对TARP在AMPA受体运输和门控的作用的关键发展，以及概述新发现的跨膜蛋白如何扩展我们对CNS中iglur功能的看法。
Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling throughout the CNS. After years of intense research, our picture of iGluRs has evolved from imagining them companionless in the postsynaptic membrane to being the hub of dynamic supramolecular signaling complexes, interacting with an ever-expanding litany of other proteins that regulate their trafficking, scaffolding, stability, signaling and turnover. In particular, the discovery that transmembrane AMPA receptor regulatory proteins (TARPs) are auxiliary subunits of AMPA receptors, that are critical determinants of their trafficking, gating and pharmacology, has changed the way we think about iGluR function. Recently, a number of novel transmembrane proteins have been uncovered that may also serve as iGluR auxiliary proteins. Here we review pivotal developments in our understanding of the role of TARPs in AMPA receptor trafficking and gating, as well as an overview of how newly discovered transmembrane proteins expand our view of iGluR function in the CNS.
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