Keeping it together: Pulmonary alveoli are maintained by a hierarchy of cellular programs.
Keeping it together: Pulmonary alveoli are maintained by a hierarchy of cellular programs.
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DOI：
10.1002/bies.201500031
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Desai TJ
中科院分区：
文献类型：
--
作者：
Logan CY;Desai TJ
The application of in vivo genetic lineage tracing has advanced our understanding of cellular mechanisms for tissue renewal in organs with slow turnover, like the lung. These studies have identified an adult stem cell with very different properties than classically understood ones that maintain continuously cycling tissues like the intestine. A portrait has emerged of an ensemble of cellular programs that replenish the cells that line the gas exchange (alveolar) surface, enabling a response tailored to the extent of cell loss. A capacity for differentiated cells to undergo direct lineage transitions allows for local restoration of proper cell balance at sites of injury. We present these recent findings as a paradigm for how a relatively quiescent tissue compartment can maintain homeostasis throughout a lifetime punctuated by injuries ranging from mild to life-threatening, and discuss how dysfunction or insufficiency of alveolar repair programs produce serious health consequences like cancer and fibrosis.
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