Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis.
Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis.
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DOI：
10.1038/s41366-021-00776-8
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Payab M
中科院分区：
文献类型：
--
作者：
Aghili SMM;Ebrahimpur M;Arjmand B;Shadman Z;Pejman Sani M;Qorbani M;Larijani B;Payab M
最近的研究表明，肥胖与冠状病毒疾病（COVID-19）的严重程度有关。我们回顾了临床研究，以阐明肥胖与COVID-19严重程度、合并症的关系，并讨论可能的机制。检索了电子数据库，包括Web of Science、PubMed、Scopus和Google Scholar，并审查了所有关于COVID-19和肥胖的研究。所有研究均由评审员根据其标题和摘要进行独立筛选。选择了40篇相关文章，并对其全文进行了审查。肥胖通过各种机制影响呼吸和免疫系统。从脂肪组织分泌的细胞因子和脂肪因子导致肥胖患者的促炎状态，使其易患血栓形成、先天性和适应性免疫应答的不协调、抗体应答不足和细胞因子风暴。肥胖患者的排毒时间较长。肥胖与其他合并症有关，如高血压、心血管疾病、糖尿病和维生素D缺乏症。肥胖患者的住院率、重症监护室入院率、机械通气率甚至死亡率均高于正常体重患者。肥胖可能会改变严重COVID-19症状向年轻人的方向发展。减少体力活动、不健康的饮食习惯以及在COVID-19大流行期间经历的更多压力和恐惧可能导致更多体重增加和肥胖。肥胖应被视为COVID-19严重程度的独立风险因素。在这场大流行期间，更加关注预防感染COVID-19的肥胖患者在疾病早期阶段体重增加至关重要。
Recent studies have shown that obesity is associated with the severity of coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms. The electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched and all studies conducted on COVID-19 and obesity were reviewed. All studies were independently screened by reviewers based on their titles and abstracts. Forty relevant articles were selected, and their full texts were reviewed. Obesity affects the respiratory and immune systems through various mechanisms. Cytokine and adipokine secretion from adipose tissue leads to a pro-inflammatory state in obese patients, predisposing them to thrombosis, incoordination of innate and adaptive immune responses, inadequate antibody response, and cytokine storm. Obese patients had a longer virus shedding. Obesity is associated with other comorbidities such as hypertension, cardiovascular diseases, diabetes mellitus, and vitamin D deficiency. Hospitalization, intensive care unit admission, mechanical ventilation, and even mortality in obese patients were higher than normal-weight patients. Obesity could alter the direction of severe COVID-19 symptoms to younger individuals. Reduced physical activity, unhealthy eating habits and, more stress and fear experienced during the COVID-19 pandemic may result in more weight gain and obesity. Obesity should be considered as an independent risk factor for the severity of COVID-19. Paying more attention to preventing weight gain in obese patients with COVID-19 infection in early levels of disease is crucial during this pandemic.
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影响因子：
3.2
作者：
Blokhin IO;Lentz SR
通讯作者：
Lentz SR
影响因子：
--
作者：
Abbas, Ahmed M;Fathy, Safaa K;Shawky, Mario S
通讯作者：
Shawky, Mario S
DOI：
10.1016/s0140-6736(16)30054-x
发表时间：
2016-04-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
NCD Risk Factor Collaboration (NCD-RisC)
通讯作者：
NCD Risk Factor Collaboration (NCD-RisC)
影响因子：
7.5
作者：
Chen, Qingqing;Zheng, Zhencang;Zheng, Cheng
通讯作者：
Zheng, Cheng
影响因子：
4.9
作者：
Collet, F.;Mallart, A.;Perez, T.
通讯作者：
Perez, T.