Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals.
Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals.
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DOI：
10.1016/j.resp.2015.02.004
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发表时间：
2015-06
影响因子：
2.3
通讯作者：
Zimba, Paul V.
中科院分区：
文献类型：
--
作者：
Gutierrez, Danielle B.;Fahlman, Andreas;Gardner, Manuela;Kleinhenz, Danielle;Piscitelli, Marina;Raverty, Stephen;Haulena, Martin;Zimba, Paul V.
海洋哺乳动物在潜水过程中反复暴露在胸外压力升高和肺泡塌陷的环境中，在吸入时很容易经历肺泡扩张--与陆地哺乳动物相比，这是一种独特的能力。海洋哺乳动物的肺如何克服频繁的肺泡塌陷和重新聚集的挑战仍然未知。最近的研究表明，与陆地哺乳动物相比，肺表面活性物质具有更多的抗黏附成分，这将有助于肺泡的开放。然而，由于齿足动物的生理和潜水行为与鳍足动物不同，其肺表面活性物质的组成还没有得到研究。本研究的目的是研究不同海洋哺乳动物肺表面活性物质的磷脂酰胆碱(PC)组成，并将其与陆地哺乳动物进行比较。我们发现，与家犬(Canus Lupus Familaris)相比，竖琴海豹(Pagophilus Groenlandicus)和加州海狮(Zalophus Calfornianus)中抗粘连PC的种类增加，而与齿目动物相比，管脚类中流态化PC的数量分别增加了16：0/14：0和16：0/16：1。与狗相比，港口江豚(齿形目的代表)并没有更高的流态化PC水平。我们的初步结果支持了之前的发现，即鳍脚类可能调整了独特的表面活性成分，使它们能够在高压下长时间潜水，而不会产生不良影响。未来的研究将需要调查其他表面活性物质成分的差异，以全面评估牙列动物的表面活性物质组成。
Marine mammals are repeatedly exposed to elevated extra-thoracic pressure and alveolar collapse during diving and readily experience alveolar expansion upon inhalation – a unique capability as compared to terrestrial mammals. How marine mammal lungs overcome the challenges of frequent alveolar collapse and recruitment remains unknown. Recent studies indicate that pinniped lung surfactant has more anti-adhesive components compared to terrestrial mammals, which would aid in alveolar opening. However, pulmonary surfactant composition has not yet been investigated in odontocetes, whose physiology and diving behavior differ from pinnipeds. The aim of this study was to investigate the phosphatidylcholine (PC) composition of lung surfactants from various marine mammals and compare these to a terrestrial mammal. We found an increase in anti-adhesive PC species in harp seal (Pagophilus groenlandicus) and California sea lion (Zalophus californianus) compared to dog (Canus lupus familiaris), as well as an increase in the fluidizing PCs 16:0/14:0 and 16:0/16:1 in pinnipeds compared to odontocetes. The harbor porpoise (a representative of the odontocetes) did not have higher levels of fluidizing PCs compared to dog. Our preliminary results support previous findings that pinnipeds may have adapted unique surfactant compositions that allow them to dive at high pressures for extended periods without adverse effects. Future studies will need to investigate the differences in other surfactant components to fully assess the surfactant composition in odontocetes.
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影响因子：
1.4
作者：
FELDKAMP, SD;DELONG, RL;ANTONELIS, GA
通讯作者：
ANTONELIS, GA
影响因子：
2.5
作者：
HUNT, AN;KELLY, FJ;POSTLE, AD
通讯作者：
POSTLE, AD
DOI：
10.1016/0034-5687(79)90042-2
发表时间：
1979-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
KOOYMAN, GL;SINNETT, EE
通讯作者：
SINNETT, EE
DOI：
10.1016/0034-5687(71)90029-6
发表时间：
1971-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
DENISON, DM;WARRELL, DA;WEST, JB
通讯作者：
WEST, JB
DOI：
10.1086/physzool.54.1.30155804
发表时间：
1981-01-01
期刊：
PHYSIOLOGICAL ZOOLOGY
影响因子：
--
作者：
KOOYMAN, GL;CORNELL, LH
通讯作者：
CORNELL, LH