Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.
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DOI：
10.1186/1475-2891-13-112
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发表时间：
2014-12-04
影响因子：
5.4
通讯作者：
Sata M
中科院分区：
文献类型：
--
作者：
Yagi S;Hara T;Ueno R;Aihara K;Fukuda D;Takashima A;Hotchi J;Ise T;Yamaguchi K;Tobiume T;Iwase T;Yamada H;Soeki T;Wakatsuki T;Shimabukuro M;Akaike M;Sata M
最近的研究表明，摄入n-3多不饱和脂肪酸（PUFA）与认知障碍和冠状动脉疾病（CAD）的风险降低有关;然而，目前尚不清楚血清n-3 PUFA降低是否与CAD患者的认知障碍有关。我们通过简易精神状态检查（MMSE）、血清PUFA水平回顾性评估了认知功能（包括二十碳五烯酸[EPA]、二十二碳六烯酸[DHA]、双高γ-亚麻酸[DGLA]和花生四烯酸[AA]）、心血管风险因素（高血压、血脂异常、糖尿病、脑血管疾病和当前/既往吸烟史），和心功能参数（左心室射血分数和脑钠肽水平）。评估MMSE评分与其他参数之间的相关性。Pearson相关分析显示，EPA（R = 0.25，P <0.01），EPA/AA比值（R = 0.22，P = 0.01），左室射血分数（R = 0.15，P = 0.04）与MMSE评分呈正相关，年龄（R =-0.20，P <0.01）和脑钠肽水平（R =-0.28，P <0.01）与MMSE评分呈负相关。多元回归分析显示，年龄（P <0.05）与MMSE评分呈负相关，而EPA评分与MMSE评分呈负相关（P <0.01）和EPA/AA比值性别、体重指数、左室射血分数、DHA、AA、DGLA水平、DHA/AA比值、脑钠素、脑钠素、脑啡肽、脑啡高血压、血脂异常、糖尿病、脑血管疾病和当前/既往吸烟史被统计学排除。血清EPA浓度与CAD患者的认知功能相关，表明低血清EPA水平是认知功能障碍的危险因素，与心功能无关，包括左心室射血分数。这种相关性可能进一步支持饮食n-3 PUFA在预防CAD患者认知能力下降中的作用。本文的在线版本（doi：10.1186/1475-2891-13-112）包含补充材料，可供授权用户使用。
Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD. We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated. Pearson correlation analysis showed that EPA (R = 0.25, P <0.01), EPA/AA ratio (R = 0.22, P = 0.01), and left ventricular ejection fraction (R = 0.15, P = 0.04) were positively associated with MMSE score, and that age (R = −0.20, P <0.01) and brain natriuretic peptide levels (R = −0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded. Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients. The online version of this article (doi:10.1186/1475-2891-13-112) contains supplementary material, which is available to authorized users.
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DOI：
10.3945/ajcn.2009.27580
发表时间：
2009-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Albanese E;Dangour AD;Uauy R;Acosta D;Guerra M;Guerra SS;Huang Y;Jacob KS;de Rodriguez JL;Noriega LH;Salas A;Sosa AL;Sousa RM;Williams J;Ferri CP;Prince MJ
通讯作者：
Prince MJ
影响因子：
--
作者：
Morris, MC;Evans, DA;Schneider, J
通讯作者：
Schneider, J
影响因子：
1.9
作者：
Tardivel, Sylviane;Gousset-Dupont, Aurelie;Lacour, Bernard
通讯作者：
Lacour, Bernard
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR
影响因子：
5.3
作者：
Matsumoto, Miwa;Sata, Masataka;Nagai, Ryozo
通讯作者：
Nagai, Ryozo