Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study.
Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study.
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DOI：
10.3945/ajcn.2009.27580
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Prince MJ
中科院分区：
文献类型：
--
作者：
Albanese E;Dangour AD;Uauy R;Acosta D;Guerra M;Guerra SS;Huang Y;Jacob KS;de Rodriguez JL;Noriega LH;Salas A;Sosa AL;Sousa RM;Williams J;Ferri CP;Prince MJ
背景：在发展中国家的人群中，鱼和肉的摄入量与痴呆症风险之间存在关联的证据是不一致的，也不存在。目的：研究低收入和中等收入国家食用鱼类和肉类与痴呆症之间的关系。设计：在中国、印度、古巴、多米尼加共和国、委内瑞拉、墨西哥和秘鲁的11个集水区，对所有65岁的≥居民进行了一期横断面调查。共有14,960名居民使用10/66标准化方案进行了评估，其中包括对饮食习惯的面对面访谈和跨文化验证的痴呆症诊断。结果：饮食摄入量和痴呆症患病率因地点而异。我们在2个固定效应模型荟萃分析中结合了特定部位的泊松回归患病率(PR)，以研究鱼和肉的消费与痴呆之间的关系，并对社会人口和健康特征以及鱼和肉的消费进行了适当的调整。我们发现，鱼的摄入量与痴呆症之间存在剂量依赖的负相关关系(PR：0.81；95%CI：0.72，0.91)，这在除印度以外的所有地点都是一致的，而肉类消费与痴呆症患病率之间不那么一致，存在剂量依赖性的直接关联(PR：1.19；95%CI：1.07，1.31)。结论：我们的结果扩展了低收入和中等收入国家人群食用鱼类和肉类与痴呆症风险相关的发现，并与鱼类中常见的omega-3(n-3)长链多不饱和脂肪酸的神经保护作用的机制数据一致。鱼和普遍的痴呆症之间的负相关不太可能是痴呆症患者较差的饮食习惯造成的(反向因果关系)，因为那些被诊断为痴呆症的人吃肉更多。
Background: Evidence of an association between fish and meat consumption and risk of dementia is inconsistent and nonexistent in populations in developing countries. Objective: The objective was to investigate associations between fish and meat consumption with dementia in low- and middle-income countries. Design: One-phase cross-sectional surveys were conducted in all residents aged ≥65 y in 11 catchment areas in China, India, Cuba, the Dominican Republic, Venezuela, Mexico, and Peru. A total of 14,960 residents were assessed by using the 10/66 standardized protocol, which includes face-to-face interviews for dietary habits and a cross-culturally validated dementia diagnosis. Results: Dietary intakes and the prevalence of dementia varied between sites. We combined site-specific Poisson regression prevalence ratios (PRs) for the association between fish and meat consumption and dementia in 2 fixed-effect model meta-analyses adjusted for sociodemographic and health characteristics and fish and meat consumption as appropriate. We found a dose-dependent inverse association between fish consumption and dementia (PR: 0.81; 95% CI: 0.72, 0.91) that was consistent across all sites except India and a less-consistent, dose-dependent, direct association between meat consumption and prevalence of dementia (PR: 1.19; 95% CI: 1.07, 1.31). Conclusions: Our results extend findings on the associations of fish and meat consumption with dementia risk to populations in low- and middle-income countries and are consistent with mechanistic data on the neuroprotective actions of omega-3 (n–3) long-chain polyunsaturated fatty acids commonly found in fish. The inverse association between fish and prevalent dementia is unlikely to result from poorer dietary habits among demented individuals (reverse causality) because meat consumption was higher in those with a diagnosis of dementia.
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影响因子：
4
作者：
Prince, M;Graham, N;Scazufca, M
通讯作者：
Scazufca, M
影响因子：
4
作者：
Laurin, Danielle;Verreault, Rene;Holub, Bruce J.
通讯作者：
Holub, Bruce J.
影响因子：
--
作者：
Morris, MC;Evans, DA;Schneider, J
通讯作者：
Schneider, J
影响因子：
7.1
作者：
Nurk, Eha;Drevon, Christian A.;Smith, A. David
通讯作者：
Smith, A. David
影响因子：
168.9
作者：
Ferri, CP;Prince, M;Scazufca, M
通讯作者：
Scazufca, M