Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.
Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.
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DOI：
10.1289/ehp.11782
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发表时间：
2009-05
影响因子：
10.4
通讯作者：
Jinot J
中科院分区：
文献类型：
--
作者：
Cooper GS;Makris SL;Nietert PJ;Jinot J
我们的目的是检查实验和流行病学研究有关的免疫相关，特别是自身免疫相关的三氯乙烯（TCE）的影响。我们对PubMed进行了文献检索，并对识别出的文章中的参考书目进行了审查。然后，我们系统地回顾了免疫相关的数据，重点是临床和免疫学特征和机制研究。在MRL+/+狼疮小鼠中进行的研究报告了与TCE或某些代谢物暴露相关的加速自身免疫反应。据报道，在饮用水中以低至0.1 mg/kg/天的剂量暴露于TCE 4周后，其影响包括抗核抗体和干扰素-γ（IFN-γ）增加以及白细胞介素-4（IL-4）分泌减少，与炎症反应一致。暴露32-48周后发现自身免疫性肝炎、炎症性皮肤病变和脱发。最近在小鼠中进行的机制实验检查了氧化应激，特别是对TCE诱导的自身免疫性疾病中脂质过氧化衍生的醛的影响。两项人体研究报告了与职业或环境TCE接触相关的IL-2或IFN-γ升高和IL-4降低。职业性接触三氯乙烯也与严重的全身性过敏性皮肤病有关，伴有全身性影响，包括肝炎。在三项硬皮病病例对照研究中，测量职业TCE暴露，男性合并优势比为2.5 [95%置信区间（CI），1.1-5.4]，女性为1.2（95% CI，0.58-2.6）。研究之间的一致性以及小鼠和人类研究之间的一致性支持TCE在自身免疫性疾病中的病因作用。需要临床前免疫标志物的多点合作和研究来进一步发展这一研究领域。
Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE). We performed a literature search of PubMed and reviewed bibliographies in identified articles. We then systematically reviewed immune-related data, focusing on clinical and immunologic features and mechanistic studies. Studies conducted in MRL+/+ lupus mice report an accelerated autoimmune response in relation to exposure to TCE or some metabolites. Effects have been reported after 4 weeks of exposure to TCE at doses as low as 0.1 mg/kg/day in drinking water and have included increased antinuclear antibodies and interferon-γ (IFN-γ) and decreased secretion of interleukin-4 (IL-4), consistent with an inflammatory response. Autoimmune hepatitis, inflammatory skin lesions, and alopecia have been found after exposures of 32–48 weeks. Recent mechanistic experiments in mice examined oxidative stress and, specifically, effects on lipid-peroxidation–derived aldehydes in TCE-induced autoimmune disease. Two studies in humans reported an increase in IL-2 or IFN-γ and a decrease in IL-4 in relation to occupational or environmental TCE exposure. Occupational exposure to TCE has also been associated with a severe, generalized hypersensitivity skin disorder accompanied by systemic effects, including hepatitis. In three case–control studies of scleroderma with a measure of occupational TCE exposure, the combined odds ratio was 2.5 [95% confidence interval (CI), 1.1–5.4] in men and 1.2 (95% CI, 0.58–2.6) in women. The consistency among the studies and the concordance between the studies in mice and humans support an etiologic role of TCE in autoimmune disease. Multisite collaborations and studies of preclinical immune markers are needed to further develop this field of research.
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影响因子：
19.6
作者：
Beaudreuil, S;Lasfargues, G;Büchler, M
通讯作者：
Büchler, M
DOI：
10.1007/s00420-003-0462-5
发表时间：
2004-01-01
影响因子：
3
作者：
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通讯作者：
Caramaschi, P
影响因子：
3.8
作者：
Cai, Ping;Konig, Rolf;Ansari, G. A. S.
通讯作者：
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影响因子：
3.8
作者：
Cai, Ping;Konig, Rolf;Ansari, G. A. S.
通讯作者：
Ansari, G. A. S.
影响因子：
3.8
作者：
Blossom, Sarah J.;Doss, Jason C.;Gilbert, Kathleen M.
通讯作者：
Gilbert, Kathleen M.