Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice.
Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice.
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虾青素对小鼠缺血/再灌注肾损伤的保护作用
DOI：
10.1186/s12967-015-0388-1
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发表时间：
2015-01-27
影响因子：
7.4
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Qiu X;Fu K;Zhao X;Zhang Y;Yuan Y;Zhang S;Gu X;Guo H
虾青素（ATX）是一种强大的抗氧化剂，天然存在于各种生物体中。已有研究表明，ATX具有清除氧自由基的作用，对缺血再灌注（IR）引起的器官损伤具有保护作用。本研究旨在进一步研究ATX对氧化应激诱导的肾小管上皮细胞毒性和IR诱导的小鼠肾损伤的保护作用。250 nM浓度的ATX可减弱100 μM H2 O2诱导的肾小管上皮细胞活力下降。在体内，ATX可保护IR后12 h或24 h的肾功能，IR前连续灌胃ATX 14 d可明显抑制IR后24 h的组织学损伤，组织学结果显示，ATX可显著降低IR后病理组织学评分、凋亡细胞数和α-平滑肌肌动蛋白的表达。此外，IR后24 h，ATX可显著降低肾脏样本中的氧化应激和炎症。总之，本研究表明，ATX预处理可通过抗氧化活性有效保护肾功能和组织学。
Astaxanthin (ATX) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Previous studies have shown that ATX has effects of eliminating oxygen free radicals and can protect organs from ischemia/reperfusion (IR) induced injury. The present study was designed to further investigate the protective effects of ATX on oxidative stress induced toxicity in tubular epithelial cells and on IR induced renal injury in mice. ATX, at a concentration of 250 nM, attenuated 100 μM H2O2-inudced viability decrease of tubular epithelial cells. In vivo, ATX preserved renal function 12 h or 24 h post IR. Pretreatment of ATX via oral gavage for 14 consecutive days prior to IR dramatically prevented IR induced histological damage 24 h post IR. Histological results showed that the pathohistological score, number of apoptotic cells, and the expression of α-smooth muscle actin were significantly decreased by pretreatment of ATX. In addition, oxidative stress and inflammation in kidney samples were significantly reduced by ATX 24 h post IR. Taken together, the current study suggests that pretreatment of ATX is effective in preserving renal function and histology via antioxidant activity.
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影响因子：
3.9
作者：
PALOZZA, P;KRINSKY, NI
通讯作者：
KRINSKY, NI
影响因子：
7.5
作者：
Chen YT;Yang CC;Zhen YY;Wallace CG;Yang JL;Sun CK;Tsai TH;Sheu JJ;Chua S;Chang CL;Cho CL;Leu S;Yip HK
通讯作者：
Yip HK
影响因子：
15.9
作者：
Melnikov, VY;Faubel, S;Edelstein, CL
通讯作者：
Edelstein, CL
astaxanthin：心血管疾病中潜在的治疗剂。
影响因子：
5.4
作者：
Fassett RG;Coombes JS
通讯作者：
Coombes JS
影响因子：
2.8
作者：
Pashkow, Fredric J.;Watumull, David G.;Campbell, Charles L.
通讯作者：
Campbell, Charles L.