Astaxanthin: a potential therapeutic agent in cardiovascular disease.
Astaxanthin: a potential therapeutic agent in cardiovascular disease.
复制标题
astaxanthin：心血管疾病中潜在的治疗剂。
DOI：
10.3390/md9030447
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发表时间：
2011-03-21
期刊：
影响因子：
5.4
通讯作者：
Coombes JS
中科院分区：
文献类型：
--
作者：
Fassett RG;Coombes JS
虾青素是一种叶黄素类胡萝卜素，存在于微藻、真菌、复杂植物、海鲜、火烈鸟和鹌鹑中。它是一种具有抗炎特性的抗氧化剂，因此具有作为动脉粥样硬化性心血管疾病的治疗剂的潜力。虾青素的合成形式已经被制造出来。虾青素的安全性、生物利用度以及对氧化应激和炎症的影响（与动脉粥样硬化性心血管疾病的病理生理学相关）已在少数临床研究中进行了评估。尚未报告不良事件，并且有证据表明施用虾青素可减少氧化应激和炎症的生物标志物。使用缺血再灌注心肌模型对多个物种进行的实验研究表明，在诱导缺血事件之前口服或静脉注射虾青素可以保护心肌。现阶段，我们不知道在心血管事件后施用虾青素是否有益，并且尚未完成和/或报告人类临床心血管研究。基于虾青素的理化和抗氧化特性、安全性和初步心血管实验研究，有必要进行心血管临床试验。
Astaxanthin is a xanthophyll carotenoid present in microalgae, fungi, complex plants, seafood, flamingos and quail. It is an antioxidant with anti-inflammatory properties and as such has potential as a therapeutic agent in atherosclerotic cardiovascular disease. Synthetic forms of astaxanthin have been manufactured. The safety, bioavailability and effects of astaxanthin on oxidative stress and inflammation that have relevance to the pathophysiology of atherosclerotic cardiovascular disease, have been assessed in a small number of clinical studies. No adverse events have been reported and there is evidence of a reduction in biomarkers of oxidative stress and inflammation with astaxanthin administration. Experimental studies in several species using an ischaemia-reperfusion myocardial model demonstrated that astaxanthin protects the myocardium when administered both orally or intravenously prior to the induction of the ischaemic event. At this stage we do not know whether astaxanthin is of benefit when administered after a cardiovascular event and no clinical cardiovascular studies in humans have been completed and/or reported. Cardiovascular clinical trials are warranted based on the physicochemical and antioxidant properties, the safety profile and preliminary experimental cardiovascular studies of astaxanthin.
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影响因子：
6.1
作者：
Gross, GJ;Lockwood, SF
通讯作者：
Lockwood, SF
影响因子：
56.9
作者：
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通讯作者：
INGOLD, KU
影响因子：
2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2007.12.019
发表时间：
2008-02-22
影响因子：
3.1
作者：
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通讯作者：
Yoshikawa, Toshikazu