Evolution patterns of SARS-CoV-2: Snapshot on its genome variants.
Evolution patterns of SARS-CoV-2: Snapshot on its genome variants.
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DOI：
10.1016/j.bbrc.2020.10.102
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发表时间：
2021-01-29
影响因子：
3.1
通讯作者：
Ciccozzi M
中科院分区：
文献类型：
--
作者：
Giovanetti M;Benedetti F;Campisi G;Ciccozzi A;Fabris S;Ceccarelli G;Tambone V;Caruso A;Angeletti S;Zella D;Ciccozzi M
由一种新型冠状病毒(SARS-CoV-2)引起的急性呼吸综合征(SARS-CoV-2)发病率高、死亡率高，是近几个世纪以来人类面临的最大威胁之一。由于SARS-CoV-2病毒的不断进化，其单核苷酸多态(SNP)变异体和多个谱系，严格确定SARS-CoV-2的传染性是非常困难的。然而，迫切需要对该病毒进行深入研究，了解其致病和毒力的机制，并制定有效的治疗策略。本报告简明扼要地概述了关于该病毒进化和结构特征的现有知识，目的是澄清其变异模式及其在当前大流行中可能发挥的作用。
An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.
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